Chemical composition and biological activities of propolis samples from different geographical regions of Turkey

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dc.authoridAltun, Mehmet MA/0000-0003-2541-0623
dc.authoridGoren, Ahmet Ceyhan/0000-0002-5470-130X
dc.authoridÖnem, Ayşe Nur/0000-0002-6201-6740
dc.authoridDemirci, Betul/0000-0003-2343-746X
dc.authoridKirci, Damla/0000-0002-3479-3999
dc.authoridKISLA, Duygu/0000-0002-6993-3883
dc.authoridSumer Okkali, Gaye/0000-0003-2756-0617
dc.authorscopusid36091846900
dc.authorscopusid57194561260
dc.authorscopusid57223934765
dc.authorscopusid57223380626
dc.authorscopusid57224629270
dc.authorscopusid57214128114
dc.authorscopusid8609499100
dc.authorwosidAltun, Mehmet MA/B-8978-2014
dc.authorwosidGoren, Ahmet Ceyhan/G-1562-2017
dc.authorwosidDemirci, Betul/AHA-2298-2022
dc.authorwosidÖnem, Ayşe Nur/C-7308-2019
dc.authorwosidKirci, Damla/GLR-4714-2022
dc.contributor.authorSarikahya, Nazli Boke
dc.contributor.authorGoren, Ahmet C.
dc.contributor.authorOkkali, Gaye Sumer
dc.contributor.authorCoven, Furkan Ozan
dc.contributor.authorOrman, Batuhan
dc.contributor.authorKirci, Damla
dc.contributor.authorYucel, Banu
dc.date.accessioned2023-01-12T19:56:11Z
dc.date.available2023-01-12T19:56:11Z
dc.date.issued2021
dc.departmentN/A/Departmenten_US
dc.description.abstractPropolis is a natural product with many biological activities, and it has been used in many industrial areas, such as pharmaceuticals, food and cosmetics. Thus, in this study, we aim to evaluate the chemical content, antioxidant, antiviral activities, cytotoxicity and the iNOS of propolis samples collected from 39 different regions in Turkey. Phenolic, flavonoid and triterpene profiles were determined using the LC-HRMS method. The main phenolic compounds identified were flavonoids, including diosmetin, rhamnocitrin, isosakuranetin, naringenin, chrysin, 3-O-methyl-quercetin and acacetin, the main phenolic acid was found as caffeic acid. The major triterpene compounds were also detected as oleanolic acid and hederagenin. The composition of volatile compounds in the propolis samples was examined using GC-MS. alpha-Pinene, beta-pinene and limonene were found as the main compounds in most of the samples. Cytotoxic activities against MDA-MB-231, PC-3, A549, HeLa and a nontumor cell line HEK293 were performed using the MIT method. The iNOS was also determined using LPS induced RAW 264.7 macrophage cells. Pmpolis samples exhibited significant cytotoxic and nitric oxide inhibition activities with a significant range of IC50 values. The total antioxidant/phenolic capacities in TR equivalents of pmpolis samples were assayed by DPPH, CUPRAC, FRAP, and Folin methods. The total phenolics content in the studied pmpolis extracts were found as between 0.96 and 13.53 mmol TR/g. TAC of propolis samples range with respect to the CUPRAC and FRAP methods were found from 0.71 to 8.24 and 0.21 to 2.27 mmol TR/g, respectively. Most of the propolis extracts exhibited more than 80 % DPPH scavenging activities, almost similar or higher than the positive controls. Antiviral activities of the samples were measured as virucidal activity by in ovo. All propolis samples promise for the significant inhibition of avian coronavirus. To our knowledge, this study is the first detailed study in the literature that includes the chemical content and biological activities of Turkish pmpolis collected from different geographical regions.en_US
dc.description.sponsorshipEge University Scientific Research Projects Coordination Unit [FGA-2020-21344]en_US
dc.description.sponsorshipThe authors are grateful to the Ege University Scientific Research Projects Coordination Unit for supporting this study (Project Number: FGA-2020-21344) .en_US
dc.identifier.doi10.1016/j.phytol.2021.06.008
dc.identifier.endpage136en_US
dc.identifier.issn1874-3900
dc.identifier.issn1876-7486
dc.identifier.issn1874-3900en_US
dc.identifier.issn1876-7486en_US
dc.identifier.scopus2-s2.0-85108108176en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage129en_US
dc.identifier.urihttps://doi.org/10.1016/j.phytol.2021.06.008
dc.identifier.urihttps://hdl.handle.net/11454/76815
dc.identifier.volume44en_US
dc.identifier.wosWOS:000693417900024en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofPhytochemistry Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPropolisen_US
dc.subjectCytotoxicityen_US
dc.subjectAntioxidanten_US
dc.subjectAntiviralen_US
dc.subjectLC-HAMSen_US
dc.subjectGC-MSen_US
dc.subjectAcid Phenethyl Esteren_US
dc.subjectAntiviral Activityen_US
dc.subjectTurkish Propolisen_US
dc.subjectIn-Vitroen_US
dc.subjectAntibacterial Activityen_US
dc.subjectAntioxidant Activityen_US
dc.subjectBrazilian Propolisen_US
dc.subjectPhenolic-Compoundsen_US
dc.subjectExtractsen_US
dc.subjectFloraen_US
dc.titleChemical composition and biological activities of propolis samples from different geographical regions of Turkeyen_US
dc.typeArticleen_US

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