Synthesis, radiolabeling and biodistribution of morphine glucuronide (mor-glu)

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dc.contributor.authorEnginar, H.
dc.contributor.authorUnak, P.
dc.contributor.authorMuftuler, F. Z. Biber
dc.contributor.authorLambrecht, F. Y.
dc.contributor.authorMedine, E. I.
dc.contributor.authorYolcular, S.
dc.contributor.authorKilcar, A. Yurt
dc.contributor.authorSeyitoglu, B.
dc.contributor.authorBulduk, I.
dc.date.accessioned2019-10-27T21:44:20Z
dc.date.available2019-10-27T21:44:20Z
dc.date.issued2012
dc.departmentEge Üniversitesien_US
dc.description.abstractThe aim of this study was to synthesize a glucuronide conjugated morphine derivative which could be labeled with I-131, as a radiopharmaceutical, and to investigate its radiopharmaceutical potential using biodistribution studies in male Albino Wistar rats. Morphine was extracted from dry capsules of the opium poppy (Papaver somniferum L.). It was conjugated with UDP-glucuronic acid by using UDP-glucuronyl transferase (UDPGT) enzyme rich microsomes, purified by high performance liquid chromatography (HPLC) and characterized by nuclear magnetic resonance (NMR), infrared (IR) spectroscopy and liquid chromatography mass spectroscopy (LC-MS/MS). Normal and receptor blockage biodistribution studies were performed in male Albino Wistar rats. The results of the tissue distribution studies showed that I-131 labeled morphine glucuronide (I-131-mor-glu) uptake in the small intestine, large intestine and urinary bladder was higher than in the other tissues of the rats in the blocked receptor and unblocked receptor. A greater uptake of the radio labeled substance was observed in the hypothalamus and mid brain than in the other branches of the rats' brains.en_US
dc.description.sponsorshipScientific and Technical Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [2004-104T187]; T.R Prime Ministry State Planning Organization [2006 DPT 06]en_US
dc.description.sponsorshipThe authors thank for the financial supports from The Scientific and Technical Research Council of Turkey (TUBITAK, Project number 2004-104T187) and T.R Prime Ministry State Planning Organization (DPT, Project Number 2006 DPT 06).en_US
dc.identifier.doi10.1007/s10967-011-1412-4
dc.identifier.endpage857en_US
dc.identifier.issn0236-5731
dc.identifier.issn0236-5731en_US
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage849en_US
dc.identifier.urihttps://doi.org/10.1007/s10967-011-1412-4
dc.identifier.urihttps://hdl.handle.net/11454/47230
dc.identifier.volume291en_US
dc.identifier.wosWOS:000300295800037en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMorphine glucuronideen_US
dc.subjectRadiolabelingen_US
dc.subjectI-131en_US
dc.subjectBiodistributionen_US
dc.subjectI-131 labeled morphine-glucuronide (I-131-mor-glu)en_US
dc.titleSynthesis, radiolabeling and biodistribution of morphine glucuronide (mor-glu)en_US
dc.typeArticleen_US

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