Key variables in managing femoral pathological fractures and search for objective parameters for decision-making

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dc.authoridvahabi, arman/0000-0002-8937-6658
dc.contributor.authorKaya, Hüseyin
dc.contributor.authorVahabi, Arman
dc.contributor.authorSabah, Dündar
dc.date.accessioned2024-08-25T18:51:56Z
dc.date.available2024-08-25T18:51:56Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractAim: Bone invasion in advanced cancers represents later stages and requires individualized treatment strategies based on patient related variables. The objective of this study is to ascertain the significance of age, location, serum levels of Ca, urea, albumin, and accordingly calculated MEP (Metastatic Early Prognostic) score, in planning the treatment of femoral impending and pathological fractures. The secondary aim was to compare complication rates between osteosynthesis and prosthetic replacement and to place this analysis on the time axis. Material and Methods: This retrospective cohort was conducted at a tertiary care hospital with a dedicated orthopedic oncology team. The database search was performed for surgically treated femoral pathological/impending fractures between 2010 and 2020. Demographic data, mortality, fracture location, levels of Ca, urea, albumin, and follow-up X-rays were collected. Surgical procedures were categorized as prosthetic replacement or osteosynthesis for comparative analysis. Complications and the necessity of secondary interventions were noted accordingly. Results: A total of 109 patients met the inclusion criteria. The average follow-up period was 9.1 months, with a mean survival time of 12.96 months. High serum urea levels, low albumin levels, high calcium levels were associated with increased one-year mortality. Osteosynthesis procedures had a higher need for secondary surgeries compared to prosthetic reconstruction. A threshold of one year has shown to be the critical limit before mechanical complications related to osteosynthesis occur. Discussion: Secondary surgery rates were higher in the fixation group with survival exceeding one year, suggesting a greater consideration for prosthetic replacement in that group. Markers such as urea, albumin, and calcium levels can provide insights into mortality rates when evaluating surgical treatment options.en_US
dc.identifier.doi10.4328/ACAM.21884
dc.identifier.endpage191en_US
dc.identifier.issn2667-663X
dc.identifier.startpage186en_US
dc.identifier.urihttps://doi.org/10.4328/ACAM.21884
dc.identifier.urihttps://hdl.handle.net/11454/102774
dc.identifier.volume14en_US
dc.identifier.wosWOS:001078582900013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherBayrakol Medical Publisheren_US
dc.relation.ispartofAnnals of Clinical and Analytical Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240825_Gen_US
dc.subjectMetastatic Bone Diseaseen_US
dc.subjectBone Metastasisen_US
dc.subjectOrthopaedic Oncologyen_US
dc.subjectMEP Scoreen_US
dc.subjectMortalityen_US
dc.subjectLife Expectancyen_US
dc.subjectBone Metastasesen_US
dc.subjectMortalityen_US
dc.subjectSurvivalen_US
dc.subjectDiseaseen_US
dc.subjectCanceren_US
dc.subjectScoreen_US
dc.subjectFemuren_US
dc.titleKey variables in managing femoral pathological fractures and search for objective parameters for decision-makingen_US
dc.typeArticleen_US

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