Effect of Levothyroxine Sodium Intake on the Fetal Fraction in Non-Invasive Prenatal Testing: A Cross-Sectional Study

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dc.authoridOZEREN, MEHMET/0000-0002-4552-9042
dc.authoridGölbaşı, Hakan/0000-0001-8682-5537
dc.authorscopusid56003553300
dc.authorscopusid57207311185
dc.authorscopusid57387774200
dc.authorscopusid57189364068
dc.authorscopusid56891780800
dc.authorscopusid57193450671
dc.authorscopusid23995432100
dc.authorwosidIlerı, Hande/AGD-6158-2022
dc.authorwosidOZEREN, MEHMET/ABI-7832-2020
dc.authorwosidGölbaşı, Hakan/AAS-6783-2021
dc.contributor.authorIleri, Alper
dc.contributor.authorYildirim Karaca, Suna
dc.contributor.authorIleri, Hande
dc.contributor.authorGolbasi, Hakan
dc.contributor.authorSahingoz Yildirim, Alkim Gulsah
dc.contributor.authorKutbay, Yasar Bekir
dc.contributor.authorKoc, Altug
dc.date.accessioned2023-01-12T20:18:51Z
dc.date.available2023-01-12T20:18:51Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractObjective: Non-invasive prenatal testing (NIPT) and fetal fraction (FF) are shown to be affected by various factors like maternal characteristics or medications. Recently medications are now undergoing evaluation as influencing factors. Still no data are presented on the relation between levothyroxine, NIPT and FF results. The study's aim is to assess the effect of levothyroxine sodium on the FF. Material and Methods: This retrospective case control study was conducted with medical records of pregnant women who underwent NIPT between 2016-2020 at our institution. Women with multiple gestation, body-mass index >= 25, abnormal fetal karyotype, pregnancy with assisted reproductive techniques, those without FF report and non-euthyroid patients were excluded. The pregnant euthyroid women included in the study were divided into two groups: using and not using levothyroxine. Maternal characteristics, FF of the NIPT, TSH, FT4 values and levothyroxine dosing were noted and compared between the two groups. Results: Data were collected from 51 pregnant women using levothyroxine and 102 pregnant women who did not. There was no difference in demographic characteristics, also no significant difference was shown in TSH and FT4 between the groups (p=0.180, p=0.920). The mean FF level in pregnant women using levothyroxine is lower, but the situation did not reach statistical significance (p=0.070). Conclusion: The knowledge of relation between FF and medications is largely based on very limited data. This is the first report of assessing levothyroxine effect on FF percentage in NIPT. Levothyroxine sodium was not confirmed to be associated with any significant change in the FF.en_US
dc.identifier.doi10.5336/jcog.2022-90002
dc.identifier.endpage110en_US
dc.identifier.issn2619-9467
dc.identifier.issn2619-9467en_US
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85140214939en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage106en_US
dc.identifier.urihttps://doi.org/10.5336/jcog.2022-90002
dc.identifier.urihttps://hdl.handle.net/11454/78947
dc.identifier.volume32en_US
dc.identifier.wosWOS:000871242900005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofJournal Of Clinical Obstetrics And Gynecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNon-invasive prenatal testingen_US
dc.subjectprenatal diagnosisen_US
dc.subjectthyroxineen_US
dc.subjectCell-Free Dnaen_US
dc.subjectMaternal Plasmaen_US
dc.titleEffect of Levothyroxine Sodium Intake on the Fetal Fraction in Non-Invasive Prenatal Testing: A Cross-Sectional Studyen_US
dc.typeArticleen_US

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