A new agent for sentinel lymph node detection: preliminary results

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dc.contributor.authorBekis, Recep
dc.contributor.authorMedine, Ilker
dc.contributor.authorDagdeviren, Kagan
dc.contributor.authorErtay, Turkan
dc.contributor.authorUnak, Perihan
dc.date.accessioned2019-10-27T21:35:45Z
dc.date.available2019-10-27T21:35:45Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractSentinel lymph node detection is widely used to identify lymph nodes that receive lymphatic drainage from a primary tumor. (99m)Tc labeled iron oxide nanoparticles were prepared to invent a new colorful radioactive agent for sentinel lymph node detection. Iron oxide nanoparticles were produced by co-precipitation of FeCl(3) and FeCl(2) in the presence of NaOH. Then iron oxide nanoparticles were labeled with (99m)Tc. (99m)Tc labeled nanoparticles (7.4 MBq/0.1 mL) were intradermally injected in the distal hind limb of 16 rabbits. Dynamic and static lymphoscintigraphic images were taken for 24 h. Labeling efficiencies of (99m)Tc-iron oxide nanoparticles were over 99%. Their sizes are between 50 and 60 nm. (99m)Tc-iron oxide nanoparticles were accumulated in the popliteal lymph node in 11 of 16 rabbits (69%). Retention of nanoparticles in the popliteal lymph node was obvious at from 2nd through 24th hours. The radioactive lymph node was identified easily by gamma probe. The popliteal lymph node was excised and established for radioactivity and black dye. These black and radioactive nanoparticles may be potential agent successfully used for sentinel lymph node detection.en_US
dc.identifier.doi10.1007/s10967-011-1250-4
dc.identifier.endpage282en_US
dc.identifier.issn0236-5731
dc.identifier.issn0236-5731en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage277en_US
dc.identifier.urihttps://doi.org/10.1007/s10967-011-1250-4
dc.identifier.urihttps://hdl.handle.net/11454/45923
dc.identifier.volume290en_US
dc.identifier.wosWOS:000295418600007en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIron oxide nanoparticlesen_US
dc.subject(99m)Tc pertechnetateen_US
dc.subjectSentinel lymph nodeen_US
dc.subjectLymphoscintigraphyen_US
dc.titleA new agent for sentinel lymph node detection: preliminary resultsen_US
dc.typeArticleen_US

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