Computational Fluid Dynamics and Numeric Analysis of Aortic Wall Shear Stress Alterations Induced by Fatty Streaks

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dc.authoridArya, Muhammad/0009-0008-7057-9296
dc.contributor.authorEvren, Vedat
dc.contributor.authorArya, Muhammad
dc.contributor.authorSagcan, Abdi
dc.contributor.authorBora, Sebnem
dc.date.accessioned2024-08-31T07:48:21Z
dc.date.available2024-08-31T07:48:21Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractAtherosclerosis, a disease of the large arteries, is the primary cause of heart disease and stroke. It often begins with the formation of fatty streaks (FS). The FS consists of subendothelial accumulations of cholesterol-engorged macrophages, called 'foam cells'. For this to happen, there needs to be a significant change in the permeability of the endothelial layer. Considering the established influence of mechanical stresses on endothelial properties, shear stress can increase the permeability of the endothelial layer. This study employs a hybrid approach, combining computational fluid dynamics (CFD) simulation with numerical analysis, on a simplified model of the aorta to Investigate Endothelial Shear Stress (ESS) changes in the FS. Our findings reveal that the presence of FS leads to quantitative changes in ESS. Further numerical analysis in MATLAB 9.14 suggests a pattern that metaphorically resembles a dam, potentially trapping 'foam cells'. In an additional aspect of this study, our findings suggest that an increase in blood flow could potentially counteract the permeability increase, thus acting as a preventative measure against atherosclerosis progression. These results underscore the importance of early intervention strategies to mitigate atherosclerosis progression.en_US
dc.identifier.doi10.3390/app14072851
dc.identifier.issn2076-3417
dc.identifier.issue7en_US
dc.identifier.scopus2-s2.0-85192571790en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.3390/app14072851
dc.identifier.urihttps://hdl.handle.net/11454/104752
dc.identifier.volume14en_US
dc.identifier.wosWOS:001201097200001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofApplied Sciences-Baselen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240831_Uen_US
dc.subjectFatty Streaksen_US
dc.subjectEndothelial Shear Stressen_US
dc.subjectMatlab Contour Ploten_US
dc.subjectBlood Flow Hybrid Analysisen_US
dc.titleComputational Fluid Dynamics and Numeric Analysis of Aortic Wall Shear Stress Alterations Induced by Fatty Streaksen_US
dc.typeArticleen_US

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