Bioevaluation of Tc-99m(I) carbonyl-radiolabeled amino acid coated magnetic nanoparticles in vivo

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dc.contributor.authorBuyukok, Onur
dc.contributor.authorUcar, Eser
dc.contributor.authorIchedef, Cigdem
dc.contributor.authorCetin, Oguz
dc.contributor.authorTeksoz, Serap
dc.date.accessioned2020-12-01T12:09:23Z
dc.date.available2020-12-01T12:09:23Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.descriptionichedef, cigdem/0000-0002-1586-9521en_US
dc.description.abstractIn this paper, amino acid coated and radiolabeled magnetic nanoparticles (MNPs) were prepared as a potential diagnostic agent. Magnetic nanoparticles were synthesized and functionalized by L-alanine and L-cysteine amino acids in one step. Besides surface functionalization, amino acid coating also provided favourable particle size. Structural characterization was performed by scanning electron microscopy. We obtained 30-38 nm and 22-30 nm diameter ranges with spherical shape for L-alanine and L-cysteine coated nanoparticles, separately. Then L-alanine and L-cysteine coated MNPs were radiolabeled with Tc-99m(I)-tricarbonyl core Tc-99m(CO)(3)-Alanine-MNP, Tc-99m(CO)(3)-Cysteine-MNP) with a labeling yield of 63 +/- 3% and 74 +/- 2%. Pure radiolabeled magnetic particles were obtained by washing them with saline solution, and the radiochemical purity of Tc-99m (CO)(3)-Alanine-MNP and Tc-99m(CO)(3)-Cysteine-MNP were found as 94.3 +/- 0.47% and 97.6 +/- 1.06% in each of the final solution, respectively. in addition, both radiolabeled nanoparticles were stabile up to 4 h at 37 degrees C temperature in vitro conditions.en_US
dc.identifier.doi10.1016/j.matchemphys.2019.121751
dc.identifier.issn0254-0584
dc.identifier.issn1879-3312
dc.identifier.issn0254-0584en_US
dc.identifier.issn1879-3312en_US
dc.identifier.urihttps://doi.org/10.1016/j.matchemphys.2019.121751
dc.identifier.urihttps://hdl.handle.net/11454/63432
dc.identifier.volume235en_US
dc.identifier.wosWOS:000491438100032en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofMaterials Chemistry and Physicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject99m-technetium tricarbonyl coreen_US
dc.subjectMagnetic nanoparticlesen_US
dc.subjectRadiolabelingen_US
dc.subjectin vivoen_US
dc.titleBioevaluation of Tc-99m(I) carbonyl-radiolabeled amino acid coated magnetic nanoparticles in vivoen_US
dc.typeArticleen_US

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