Postmastectomy Radiotherapy Decision for Patients without Lymph Node Metastases: Turkish Radiation Oncology Society Breast Cancer Working Group

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dc.contributor.authorAltinok, Ayse
dc.contributor.authorGursel, Bilge
dc.contributor.authorErgen, Sefika Arzu
dc.contributor.authorAlanyall, Senem
dc.contributor.authorOzsaran, Zeynep
dc.contributor.authorAy Eren, Ayfer
dc.contributor.authorMetcalfe, Evrim
dc.contributor.authorAkmansu, Muge
dc.contributor.authorTepetam, Huseyin
dc.contributor.authorAltinok, Pelin
dc.contributor.authorAltmisdortoglu, Ozgur
dc.contributor.authorSerarslan, Alparslan
dc.contributor.authorBese, Nuran
dc.date.accessioned2019-10-27T09:47:14Z
dc.date.available2019-10-27T09:47:14Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractOBJECTIVE Recent meta-analysis have not revealed any positive effects of postmastectomy radiotherapy (PMRT) on locoregional recurrence (LRR) or overall survival in axilla-negative patients. However, risk of LRR increases to 15% in the presence of two or more adverse factors for the same patient group. In this study, PMRT indications and volume selections of radiation oncologists in Turkey for axilla-negative breast cancer was investigated. METHODS Questionnaires were distributed to members of the breast cancer study group. Data of patients with axillary negative or isolated/micrometastasis and PMRT over 10 years (2006-2016) were collected from 10 participating centers. Clinical and tumor histopathological features and treatment details of 185 patients were analyzed. RESULTS The median age of patients was 48 years. Ratio of early-stage patients was 60% (T1-15%,T2-45%). There were 147 (79%) negative cases, 32 (17%) with micrometastasis, and 6 (3%) with isolated tumor cells. Half of the patients had only their chest walls (CW) irradiated. Peripheral lymphatics were also included in the rest. In Nmic cases, ratio of irradiation of supraclavicular and axillary lymph nodes with CW were statistically significant compared to CW irradiation (72% and 28%, respectively; p=0.015). CONCLUSION Considering the low number of patients treated over 10 years in 10 different centers in Turkey, it can be said that PMRT is often done in node-negative breast cancer. It is difficult to reach a definite conclusion for patients with Nmic, due to lack of data from patients with PMRT. However, the general tendency is to irradiate peripheral lymphatics in Nmic cases if PMRT is to be performed.en_US
dc.identifier.doi10.5505/tjo.2019.1955
dc.identifier.endpage173en_US
dc.identifier.issn1300-7467
dc.identifier.issn1300-7467en_US
dc.identifier.issue3en_US
dc.identifier.startpage168en_US
dc.identifier.urihttps://doi.org/10.5505/tjo.2019.1955
dc.identifier.urihttps://hdl.handle.net/11454/29380
dc.identifier.volume34en_US
dc.identifier.wosWOS:000483636700005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofTurk Onkoloji Dergisi-Turkish Journal of Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAxillary node negativeen_US
dc.subjectmastectomyen_US
dc.subjectradiotherapyen_US
dc.titlePostmastectomy Radiotherapy Decision for Patients without Lymph Node Metastases: Turkish Radiation Oncology Society Breast Cancer Working Groupen_US
dc.typeArticleen_US

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