Fiber enriched diets and radiation induced injury of the gut

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dc.contributor.authorKapkac, M
dc.contributor.authorErikoglu, M
dc.contributor.authorTuncyurek, P
dc.contributor.authorErsin, S
dc.contributor.authorEsassolak, M
dc.contributor.authorAlkanat, M
dc.contributor.authorSipahioglu, O
dc.date.accessioned2019-10-27T18:41:46Z
dc.date.available2019-10-27T18:41:46Z
dc.date.issued2003
dc.departmentEge Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the effect of fiber-enriched defined formula diets (DFDs) on radiation-induced enteropathy. Forty-five male Sprague-Dawley rats were assigned randomly after abdominal irradiation to one of three groups (15 in each group): a fiber-free DFD group, a non-soluble fiber-enriched DFD group, and a soluble fiber-enriched DFD group. They kept their diets respectively for seven days. On day eight, the mesenteric lymph nodes were harvested for bacterial translocation, and segments of jejenum and colon were sampled for microscopic examination. The rats in the fiber-enriched DFD groups lost significantly less body weight than the rats in the fiber-free DFD group. The intestinal structure was the worst in the fiber-free DFD group, intermediate in the soluble fiber-enriched DFD group, and the best in the non-soluble fiber-enriched DFD group with significantly higher measures of villous height and jejunal mucosal thickness. These findings suggest that fiber-enriched DFD may effectively protect intestinal structure against radiation-induced damage by improving mucosal integrity. (C) 2003 Elsevier Science Inc. All rights reserved.en_US
dc.identifier.doi10.1016/S0271-5317(02)00490-6
dc.identifier.endpage83en_US
dc.identifier.issn0271-5317
dc.identifier.issn0271-5317en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage77en_US
dc.identifier.urihttps://doi.org/10.1016/S0271-5317(02)00490-6
dc.identifier.urihttps://hdl.handle.net/11454/37052
dc.identifier.volume23en_US
dc.identifier.wosWOS:000180640900009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofNutrition Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectfiberen_US
dc.subjectradiationen_US
dc.subjectbacterial translocationen_US
dc.subjectenteral feedingen_US
dc.titleFiber enriched diets and radiation induced injury of the guten_US
dc.typeArticleen_US

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