Effects of two different eight-week walking programs on insulin resistance and ER stress-related markers in pre-menopausal women

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dc.contributor.authorDogru, Yeliz
dc.contributor.authorBuyukyazi, Gurbuz
dc.contributor.authorUlman, Cevval
dc.contributor.authorTaneli, Fatma
dc.contributor.authorTikiz, Hakan
dc.contributor.authorGoral, Mehmet
dc.contributor.authorEsen, Hasan
dc.date.accessioned2019-10-27T11:25:51Z
dc.date.available2019-10-27T11:25:51Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: The relationship between exercise and endoplasmic reticulum (ER) stress, insulin resistance, and obesity is a new field of research. To our knowledge, there are no studies examining the effects of walking exercises on ER stress related markers and insulin resistance in pre-menopausal women. To examine the effect of two different eight-week walking programs on the tumor necrosis factor-alpha (TNF-alpha), Fetuin-A (alpha 2 - Heremans Schmid glycoprotein), c-Jun N-terminal kinase-1 (JNK-1) and retinol-binding protein-4 (RBP-4), the related markers of ER stress and insulin resistance in pre-menopausal women. Methods: Exercise groups (moderate tempo walking group; MTWG; n=11; brisk walking group BWG; n= 12) walked five days a week, starting from 30 minutes, gradually increasing up to 51 minutes. BWG walked at similar to 70-75% and MTWG at similar to 50-55 of HRRmax. Body mass index (BMI), body fat percentage (%), VO2max, serum TNF-alpha, Fetuin-A, JNK-1, RPB-4, blood lipids, and insulin resistance levels were determined before and after the intervention. Results: VO2max increased in both exercise groups favoring BWG; RBP-4 decreased in both exercise groups (p<0.05). Serum TNF-alpha and, TG (p<0.05), BMI and percent body fat (p<0.01), and insulin levels reduced significantly in BWG (p<0.05). The reductions observed in both exercise groups in insulin resistance, and the increases determined in the negative levels of JNK-1 in BWG may be clinically important. Conclusion: Both type of walking resulted in similar positive effects on RBP-4. The reduction observed in TNF-alpha, RBP-4, and the increases in the negative levels of JNK-1 in BWG show the positive effects of brisk walking on ER stress. The reduction in insulin resistance in relation to the possible reductions in ER stress and apoptosis in BWG may be more effective to prevent metabolic diseases.en_US
dc.description.sponsorshipCelal Bayar University Academic Research Foundationen_US
dc.description.sponsorshipThis study was funded by Celal Bayar University Academic Research Foundation.en_US
dc.identifier.doi10.1515/tjb-2016-0047
dc.identifier.endpage330en_US
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issn0250-4685en_US
dc.identifier.issn1303-829Xen_US
dc.identifier.issue5en_US
dc.identifier.startpage322en_US
dc.identifier.urihttps://doi.org/10.1515/tjb-2016-0047
dc.identifier.urihttps://hdl.handle.net/11454/33437
dc.identifier.volume41en_US
dc.identifier.wosWOS:000387205800003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofTurkish Journal of Biochemistry-Turk Biyokimya Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectWalking exercisesen_US
dc.subjectPremenopausal womenen_US
dc.subjectEstimated VO2maxen_US
dc.subjectEndoplasmic reticulum stressen_US
dc.subjectInsulin resistanceen_US
dc.subjectObesityen_US
dc.titleEffects of two different eight-week walking programs on insulin resistance and ER stress-related markers in pre-menopausal womenen_US
dc.typeArticleen_US

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