Antimicrobial activity of propolis and gentamycin against methicillin-resistant Staphylococcus aureus in a 3D thermo-sensitive hydrogel

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dc.contributor.authorGezgin, Yuksel
dc.contributor.authorKazan, Aslihan
dc.contributor.authorUlucana, Fulden
dc.contributor.authorYesil-Celiktas, Ozlem
dc.date.accessioned2019-10-27T09:41:01Z
dc.date.available2019-10-27T09:41:01Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractThe antibiotic resistance has become a major public health problem globally. Combinatorial administration of natural compounds and antibiotics is an alternative approach, particularly if synergistic effects can be elicited against multi-drug resistant bacteria. The aim of this study was to investigate the combinatorial activity of propolis and gentamycin against methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300 in three dimensional (3D) thermo-sensitive hydrogel (Poloxamer 407 25% (w/w)) to mimic the microenvironment realistically. Rheological properties, sol-gel transition temperature and the porosity of the hydrogel were determined. Subsequently, thermo-sensitive gel was loaded with propolis and gentamycin for evaluation of the combined effect. The fractional inhibitory concentration indices showed marked synergy and partial synergy without and within 3D termo-sensitive hydrogel at a range of 0.38 to 0.56, respectively. This 3D platform can be utilized to screen potential antimicrobial compounds and readily expanded to other microbial species.en_US
dc.identifier.doi10.1016/j.indcrop.2019.111588
dc.identifier.issn0926-6690
dc.identifier.issn1872-633X
dc.identifier.issn0926-6690en_US
dc.identifier.issn1872-633Xen_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1016/j.indcrop.2019.111588
dc.identifier.urihttps://hdl.handle.net/11454/28564
dc.identifier.volume139en_US
dc.identifier.wosWOS:000484646900040en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofIndustrial Crops and Productsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPropolisen_US
dc.subjectThermo-sensitive hydrogelen_US
dc.subject3Den_US
dc.subjectAntimicrobial activityen_US
dc.subjectMethicillin-Resistanten_US
dc.subjectStaphylococcus aureusen_US
dc.titleAntimicrobial activity of propolis and gentamycin against methicillin-resistant Staphylococcus aureus in a 3D thermo-sensitive hydrogelen_US
dc.typeArticleen_US

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