Effect of a plant origin drug on the biodistribution of Tc-99m-DTPA in Wistar albino rats

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dc.contributor.authorZora, Hasan
dc.contributor.authorMuftuler, Zumrut F. Biber
dc.contributor.authorDemir, Ilknur
dc.contributor.authorKilcar, Ayfer Yurt
dc.contributor.authorIchedef, Cigdem
dc.contributor.authorUnak, Perihan
dc.date.accessioned2019-10-27T21:44:21Z
dc.date.available2019-10-27T21:44:21Z
dc.date.issued2012
dc.departmentEge Üniversitesien_US
dc.description.abstractIn recent years all over the world, medicinal plants are used quite a lot but side effects of biological and chemical contents and radiopharmaceutical interactions for each consumer in question aren't entirely well-known. The studies of plant origin drug interaction with radiopharmaceuticals are highly relevant and desired. One of them is passiflora syrup (Passiflora incarnata L., Passifloraceae) which is widely used for depression, insomnia, anxiety and menopause period. The aim of current study is to evaluate possible effects of passiflora syrup on the biodistribution of Tc-99m-DTPA and its blood cells uptake. DTPA was labeled with Tc-99m radionuclide. Biodistribution studies were performed on male Wistar albino rats which were treated via oral feeding-gavage-method with either passiflora syrup or 0.9 % NaCl as control group for ten days. Blood samples were obtained by cardiac blood withdrawal from the rats and they were radiolabeled. The biodistribution results showed that the passiflora syrup decreased the uptake of Tc-99m-DTPA in kidneys and in blood cells. Tc-99m-DTPA being used widely as a kidney diagnostic agent in nuclear medicine seems to be interacting with orally taken passiflora. Passiflora syrup may modify the uptake of Tc-99m-DTPA by kidney. The knowledge of this negative effect may contribute to reduce the risk of misdiagnosis and/or repetition of the examinations in nuclear medicine.en_US
dc.description.sponsorshipEge UniversityEge University [2008 NBE 008]en_US
dc.description.sponsorshipThe authors thank MSc. student Eser UCAR for technical help. This work is supported by Ege University Research Fund (contract no 2008 NBE 008).en_US
dc.identifier.doi10.1590/S0102-695X2011005000169
dc.identifier.endpage349en_US
dc.identifier.issn0102-695X
dc.identifier.issn0102-695Xen_US
dc.identifier.issue2en_US
dc.identifier.startpage344en_US
dc.identifier.urihttps://doi.org/10.1590/S0102-695X2011005000169
dc.identifier.urihttps://hdl.handle.net/11454/47233
dc.identifier.volume22en_US
dc.identifier.wosWOS:000299742200014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSoc Brasileira Farmacognosiaen_US
dc.relation.ispartofRevista Brasileira De Farmacognosia-Brazilian Journal of Pharmacognosyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectblood cellsen_US
dc.subjectbiodistributionen_US
dc.subjectdrug interactionen_US
dc.subjectPassiflora syrupen_US
dc.subjectTc-99m-DTPAen_US
dc.subjectWistar albino raten_US
dc.titleEffect of a plant origin drug on the biodistribution of Tc-99m-DTPA in Wistar albino ratsen_US
dc.typeArticleen_US

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