The single or combined use of urine cytology, NMP22 test and telomerase test sufficient to detection of the recurrent superficial bladder tumors? [İdrar NMP22 testi·, telomeraz testi·ve si·toloji·?i?in tek veya bi·rli·kte kullanimlari yüzeyel mesane tümörü nüksleri·ni·n tanisinda yeterli·olabi·l·ir ?i?]
Küçük Resim Yok
Tarih
2006
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Introduction: In this study we aimed to compare the effectiveness of single or combined use of urine cytology, urine NMP22 test and urine telomerase level assessment in estimating recurrence in patients treated for superficial transitional epithelial carcinoma of the bladder with cystoscopy. Materials and Methods: 30 patients with superficial bladder tumors treated and followed for recurrence were included in the study. Existence of NMP22, telomerase levels in urine was investigated. Additionally, cytological evaluation of urine was performed before cystoscopy. Specificity and sensitivity of the single or combined use of NMP22, urine telomerase level and cytology were determined. Diagnostic performance of the test results was evaluated by ROC curves and Spearman correlation test was performed. Results: The sensitivity and specificity of urine NMP22 levels in the detection of superficial bladder tumors recurrence were 50% and 94%, respectively. Although the specificity of urine telomerase assessment and cytology were the highest (%100), their sensitivities were 16% and 8%, respectively. The sensitivity of NMP22 test increased when combined with telomerase assay or cytology. However, no difference was detected in the specificity of NMP22 with any combinations. The sensitivity and specificity of triple combination of tests were 66% and 94%, respectively. Statistical correlation was detected between NMP22 and cystoscopy (p=0.008). The double or triple combinations of NMP22 test with telomerase test and cytology were also in correlation with tumor recurrence (p<0.001). In terms of diagnostic value, there was no statistically significant difference determined on single use of NMP22, telomerase and cytology (p>0.05). The diagnostic performance of double or triple combination of NMP22 with telomerase assessment or cytology NMP22 was statistically significant (p<0.05). Conclusion: Until the establishment of any tests to detect bladder tumor recurrence with acceptable accuracy, the guidance of tumor markers during diagnostic process and periodical cystoscopic evaluation is considered to be a reliable method.
Açıklama
Anahtar Kelimeler
Cystoscopy, NMP22, Recurrence, Superficial bladder cancer, Telomerase
Kaynak
Turk Uroloji Dergisi
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
32
Sayı
4
