NK cells in prostate cancer

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dc.authorscopusid56364984200
dc.authorscopusid12645794600
dc.authorscopusid23010344800
dc.authorscopusid56009604300
dc.contributor.authorAcikgoz E.
dc.contributor.authorSati L.
dc.contributor.authorSoner B.C.
dc.contributor.authorOktem G.
dc.date.accessioned2023-01-12T20:22:34Z
dc.date.available2023-01-12T20:22:34Z
dc.date.issued2021
dc.departmentN/A/Departmenten_US
dc.description.abstractAdvanced modalities in the treatment of prostate cancer, an important health problem among men, draw attention to the field of cancer immunotherapy. Although the immune system holds promise for prostate cancer treatment, the biological processes associated with prostate cancer cells and immune cells have not yet been fully elucidated. The prostate cancer microenvironment is a complex system containing a large number of immune cells. Among multiple immune cells, natural killer (NK) cells have enormous potential in targeting various cancer cells. NK cells, which are an important part of the innate immune system, play a very important role as a first-line defense against prostate cancer cells. Various strategies have been adopted by researchers to increase the efficiency of NK cells. However, there are many difficulties to increase the therapeutic relevance of NK cells. This review will provide a perspective on the phenotypic and functional properties of NK cells, molecular links between NK cells and prostate cancer cells, and the therapeutic and prognostic significances of NK cells in both advanced hormone naïve prostate cancer and castration-resistant prostate cancer. © 2021 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/B978-0-12-824375-6.00019-9
dc.identifier.endpage457en_US
dc.identifier.isbn9780128243756; 9780128243961
dc.identifier.scopus2-s2.0-85138427954en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage439en_US
dc.identifier.urihttps://doi.org/10.1016/B978-0-12-824375-6.00019-9
dc.identifier.urihttps://hdl.handle.net/11454/79510
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofSuccesses and Challenges of NK Immunotherapy: Breaking Tolerance to Cancer Resistanceen_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCytotoxicityen_US
dc.subjectImmunotherapyen_US
dc.subjectNatural killer cellsen_US
dc.subjectProstate canceren_US
dc.titleNK cells in prostate canceren_US
dc.typeBook Chapteren_US

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