Ionic liquid-hydrogel hybrid material for enhanced electron transfer and sensitivity towards electrochemical detection of methamphetamine

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dc.authoridGhorbanizamani, Faezeh/0000-0001-8541-0540
dc.authoridMOULAHOUM, Hichem/0000-0003-3934-6415
dc.authorscopusid57199103659
dc.authorscopusid57188963997
dc.authorscopusid57564391200
dc.authorscopusid6701638388
dc.authorwosidGhorbanizamani, Faezeh/ABE-3800-2021
dc.authorwosidMOULAHOUM, Hichem/DIC-3335-2022
dc.contributor.authorGhorbanizamani, Faezeh
dc.contributor.authorMoulahoum, Hichem
dc.contributor.authorCelik, Emine Guler
dc.contributor.authorTimur, Suna
dc.date.accessioned2023-01-12T19:55:46Z
dc.date.available2023-01-12T19:55:46Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractReliable onsite biosensors for detecting drugs of abuse are of critical importance for the current society. Electrochemical sensors, especially screen-printed electrode (SPE)-based sensors, are a strong candidate for onsite drug detection. Although many SPE-based sensors are being developed, enhancing these tools' sensitivity and analytical capacity is a continuous endeavor. Here, we propose a novel approach for SPE surface modification using a combination of hydrogel, ionic liquid, and specific antibodies to detect methamphetamine in human saliva samples. The hydrogel-ionic liquid (ionogel) was synthesized from gelatin, PEG, and 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide. FTIR and SEM were used to characterize the material before it was applied over a screen-printed gold electrode for electrochemical measurements using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). After optimization, the calibration of the proposed sensor showed a detection range between 5.0 and 1000 ng/mL with a LOD = 0.56 ng/mL in PBS. Application of the sensor with spiked human saliva demonstrated enhanced sensitivity with a LOD = 0.72 ng/mL. The repeatability and reproducibility of the proposed biosensor demonstrated a coefficient of variance (CV%) reaching 6.92% and 2.53%, respectively. The biosensor showed a high specificity toward methamphetamine compared to other interferents. The current ionogel-based electrochemical immunosensor offers a promising and versatile tool for sensitive onsite detection of substance abuse. (C) 2022 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipRepublic of Turkey-Ministry of Development [2016K121190]en_US
dc.description.sponsorshipThe Republic of Turkey-Ministry of Development supported the infrastructure of EGE MATAL (Ege University/Izmir) via the 2016K121190 grant.en_US
dc.identifier.doi10.1016/j.molliq.2022.119627
dc.identifier.issn0167-7322
dc.identifier.issn1873-3166
dc.identifier.issn0167-7322en_US
dc.identifier.issn1873-3166en_US
dc.identifier.scopus2-s2.0-85132737015en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.molliq.2022.119627
dc.identifier.urihttps://hdl.handle.net/11454/76747
dc.identifier.volume361en_US
dc.identifier.wosWOS:000832893300015en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal Of Molecular Liquidsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIonic gelen_US
dc.subjectHydrogelen_US
dc.subjectBio sensoren_US
dc.subjectElectrochemistryen_US
dc.subjectMethamphetamineen_US
dc.subjectSalivaen_US
dc.subjectVoltammetric Determinationen_US
dc.subjectGold Nanoparticlesen_US
dc.subjectImmunosensoren_US
dc.subjectIonogelsen_US
dc.subjectIlliciten_US
dc.subjectDrugsen_US
dc.titleIonic liquid-hydrogel hybrid material for enhanced electron transfer and sensitivity towards electrochemical detection of methamphetamineen_US
dc.typeArticleen_US

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