Preparation and bioevaluation of Tc-99m-carbonyl complex of guanine

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dc.contributor.authorIchedef, Cigdem
dc.contributor.authorTeksoz, Serap
dc.contributor.authorSenocak, Kamile
dc.contributor.authorUcar, Eser
dc.contributor.authorKilcar, Ayfer Yurt
dc.date.accessioned2019-10-27T21:36:48Z
dc.date.available2019-10-27T21:36:48Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractThe aim of this study is to prepare radiolabeled guanine with Tc-99m(CO) (3) (+) core. For this purpose, guanine has been radiolabeled with Tc-99m(CO) (3) (+) core. Quality control study of radiolabeled guanine molecule with Tc-99m(CO) (3) (+) core was performed by thin layer radio chromatography (TLRC) and high performance liquid radio chromatography (HPLRC). The results showed that the radiolabeling yield was quite high (94 +/- A 3%). Beside that Tc-99m(CO)(3)-Gua complex has showed good in vitro stability during the 24 h period. Radiopharmaceutical potential of this complex was evaluated in Wistar Albino Rats. It was concluded that Tc-99m(CO)(3)-Gua could be used as a nucleotide radiopharmaceutical for in vivo applications.en_US
dc.description.sponsorshipEge University (Bornova Izmir, Turkey)Ege University [2007NBE003]en_US
dc.description.sponsorshipThis study was financially supported by the Ege University Scientific Research Project numbered 2007NBE003 (Bornova Izmir, Turkey).en_US
dc.identifier.doi10.1007/s10967-011-1164-1
dc.identifier.endpage849en_US
dc.identifier.issn0236-5731
dc.identifier.issn0236-5731en_US
dc.identifier.issue3en_US
dc.identifier.startpage845en_US
dc.identifier.urihttps://doi.org/10.1007/s10967-011-1164-1
dc.identifier.urihttps://hdl.handle.net/11454/46120
dc.identifier.volume289en_US
dc.identifier.wosWOS:000293029200025en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGuanineen_US
dc.subjectTc-99m(CO)(3)(+)en_US
dc.subjectRadiolabelingen_US
dc.subjectBiodistributionen_US
dc.titlePreparation and bioevaluation of Tc-99m-carbonyl complex of guanineen_US
dc.typeArticleen_US

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