Study on prophylactic efficacies of daptomycin and vancomycin in a rat model of MRSA infection secondary to spinal implantation [Spinal enstrümantasyon sonrasi{dotless} MRSA enfeksiyonu oluşturulmuş rat modeli üzerinde vankomisin ve daptomisin'in profilaktik etkileri]
Küçük Resim Yok
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The present study aims to investigate the prophylactic effects of daptomycin and vancomycin in an experimental spinal infection induced by spinal implantation. The study involved inoculation of a bacterial suspension prepared with the MRSA ATCC 43300 strain to the implant bed and to the peripheral tissue immediately the implantation of titanium spinal implants to the bone in adult Winstar rats. The animals were divided into three groups; seven rats in the first group received no antibiotics, while the seven rats in group two and eight rats in group three received daptomycin and vancomycin, respectively. Microbiological and histological assessments were carried out on rats with induced infections. In the swab cultures of deep surgical areas, vancomycin demonstrated inhibition of infection of the surgical site in half of animals (50%) whereas daptomycin exhibited the same effect in more animals (71.4%), which was statistically significant compared to the control group (p<0.05). In the implant and bone culture, a statistically significant superiority was not observed in prophylactically treated with either antibiotic and nontreated control group (p>0.05). As a result; comparing control group, preventive effects of daptomycin and vancomycin in infection induced model of spinal implantation with high bacteria inoculums were not found statistically significant whereas daptomycin showed statistically significant inhibition on deep surgical area infection.
Açıklama
Anahtar Kelimeler
Daptomycin, Infection, Spinal implantation, Vancomycin
Kaynak
Journal of Neurological Sciences
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
30
Sayı
4
