The Effect of Aminoglycosides on Colistin-Containing Regimens in the Treatment of Carbapenem-Resistant Gram-Negative Infections in Pediatric Intensive Care Units: A Two-Center Experience

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dc.contributor.authorBal, Zumrut Sahbudak
dc.contributor.authorKamit, Fulya
dc.contributor.authorDuyu, Muhterem
dc.contributor.authorYazici, Pinar
dc.contributor.authorAnil, Ayse Berna
dc.contributor.authorYilmaz, Dilek Ciftdogan
dc.contributor.authorYilmaz, Nisel Ozkalay
dc.contributor.authorCilli, Feriha
dc.contributor.authorKarapinar, Bulent
dc.date.accessioned2019-10-27T09:41:27Z
dc.date.available2019-10-27T09:41:27Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: This study aimed to assess the outcomes including morbidity and mortality of carbapenem-resistant gram-negative (CRGN) infections in pediatric critical care setting. The second aim was to investigate the impact of aminoglycosides on colistin-containing regimen in CRGN-infected pediatric critical care patients. Materials and Methods: We retrospectively evaluated medical records of 82 patients who had received colistin in combination with an aminoglycoside (CA group) or another antibiotic (CO group) at two reference pediatric intensive care units (PICUs) between February 2011 and February 2016. Results: We enrolled 82 CRGN-infected patients who were admitted to PICUs of two hospitals. The median age of the patients was 24 (25th-75th percentile; 8-78.75) months, and the median duration of hospital stay was 30 days (25th-75th percentile; 16.7-57.7). No statistical difference was observed in the variables, including microbiological response, attributable mortality, crude mortality, and the duration of achieving first negative culture (p>0.05). Clinical response was significantly more observed in the CA group (85.5% vs. 63.2; p=0.048), and attributable mortality was higher in the CO group (12.7% vs. 31.6%; p=0.055). Nephrotoxicity did not show statistical difference between groups (p=0.357), and neurotoxicity was not observed. Conclusion: Colistin-containing regimen in combination with an aminoglycoside may be an effective and safe antimicrobial agent without a significant increase in side effects.en_US
dc.identifier.doi10.14744/etd.2019.76093
dc.identifier.endpage287en_US
dc.identifier.issn2149-2247
dc.identifier.issn2149-2549
dc.identifier.issn2149-2247en_US
dc.identifier.issn2149-2549en_US
dc.identifier.issue3en_US
dc.identifier.startpage282en_US
dc.identifier.urihttps://doi.org/10.14744/etd.2019.76093
dc.identifier.urihttps://hdl.handle.net/11454/28630
dc.identifier.volume41en_US
dc.identifier.wosWOS:000485683800010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherErciyes Univ Sch Medicineen_US
dc.relation.ispartofErciyes Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPediatric critical care uniten_US
dc.subjectcolistinen_US
dc.subjectaminoglycosideen_US
dc.subjectcarbapenem-resistant enterobacteriaceaeen_US
dc.titleThe Effect of Aminoglycosides on Colistin-Containing Regimens in the Treatment of Carbapenem-Resistant Gram-Negative Infections in Pediatric Intensive Care Units: A Two-Center Experienceen_US
dc.typeArticleen_US

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