The use of Lamivudine-loaded PLGA nanoparticles in the diagnosis of lung cancer: Preparation, characterization, radiolabeling with Tc-99m and cell binding

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dc.authoridÖztürk, A. Alper/0000-0001-9596-0538
dc.authoridÖZDEMİR, DERYA İLEM/0000-0002-1062-498X
dc.authorscopusid56661951100
dc.authorscopusid57197223304
dc.authorscopusid25825608600
dc.authorscopusid55748265800
dc.authorwosidÖztürk, A. Alper/K-2575-2019
dc.authorwosidÖZDEMİR, DERYA İLEM/ABB-6717-2020
dc.contributor.authorEkinci, Meliha
dc.contributor.authorOzturk, A. Alper
dc.contributor.authorSantos-Oliveira, Ralph
dc.contributor.authorIlem-Ozdemir, Derya
dc.date.accessioned2023-01-12T19:55:13Z
dc.date.available2023-01-12T19:55:13Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractLung cancer is the leading cause of death (male and female) globally, responsible for over 1.8 million deaths. Although there have been some advances in the treatment of lung cancer, the early detection remains an issue globally. The necessity of new drugs able to efficiently accumulate and image lung cancer is quite required. In this study was developed PLGA nanoparticles loaded with Lamivudine (PLGA-NPs-LAM). The PLGA-NPs-LAM was characterized, radiolabeled with radioactive technetium (Tc-99m), and in vitro evaluated. The results showed a medium size of 203.667 +/- 1.436 nm, with a PDI value of 0.063 +/- 0.052, and a superficial charge of-4.597 +/- 0.368 mV. The entrapment efficacy demonstrated was 48.346 +/- 1.742% of LAM. Radiolabeling of PLGA-NPs-LAM with Technetium-99 m (Tc-99m) showed high efficiency (> 93%). The in vitro assay human lung cancer (A-549) and human fibroblast (L-929) cell lines showed that the NPs were higher uptake in A-549 line than L-929. The data demonstrated that [Tc-99m]Tc-PLGA-NPs-LAM may be a promising agent for lung cancer diagnosis.en_US
dc.identifier.doi10.1016/j.jddst.2022.103139
dc.identifier.issn1773-2247
dc.identifier.issn2588-8943
dc.identifier.issn1773-2247en_US
dc.identifier.issn2588-8943en_US
dc.identifier.scopus2-s2.0-85123888191en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.jddst.2022.103139
dc.identifier.urihttps://hdl.handle.net/11454/76638
dc.identifier.volume69en_US
dc.identifier.wosWOS:000788097500005en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal Of Drug Delivery Science And Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLamivudineen_US
dc.subjectNanoparticlesen_US
dc.subjectTechnetium-99men_US
dc.subjectRadiolabelingen_US
dc.subjectRadiopharmaceuticalsen_US
dc.subjectLung cancer diagnosisen_US
dc.subjectClinical-Trialsen_US
dc.subjectBiodistributionen_US
dc.titleThe use of Lamivudine-loaded PLGA nanoparticles in the diagnosis of lung cancer: Preparation, characterization, radiolabeling with Tc-99m and cell bindingen_US
dc.typeArticleen_US

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