Radioiodine labeled CdSe/CdS quantum dots: Lectin targeted dual probes

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dc.contributor.authorAkca, Ozlet
dc.contributor.authorUnak, Perihan
dc.contributor.authorMedine, E. Ilker
dc.contributor.authorSakarya, Serhan
dc.contributor.authorKilcar, Ayfer Yurt
dc.contributor.authorIchedef, Cigdem
dc.contributor.authorBekis, Recep
dc.contributor.authorTimur, Suna
dc.date.accessioned2019-10-27T22:13:33Z
dc.date.available2019-10-27T22:13:33Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractCdSe/CdS quantum dots (QD) were synthesized and bioconjugated with Sambucus nigra agglutinin (SNA) lectin (Lec). Mannose triflate and cysteamine molecules (MTC) were also utilized to prepare MTC-QDs and MTC-QDs-Lec probes as well as Lec bound QDs. Afterwards; potential use of these nanoparticles as radiolabeled fluorescence nano-probes for the cell imaging studies has been investigated. Biological activities of I-125(-), I-125-MTC-QDs, MTC-QDs- Lec-I-125, QDs-Lec-I-125 and Lec-I-125 were examined on various cancer cell lines such as Caco-2, MCF-7 and A-549 in terms of cell incorporation. QDs-Lec-I-125 exhibited the highest cell incorporation on whole cell lines. In addition, the QDs-Lec-I-131, was used for in vivo imaging. The whole body distribution of the radiolabeled QDs on New Zealand rabbits and Balb C mice were examined by taking dynamic and static images. Radioactivity cleared from the kidneys and the bladder, while significant amount radioactivity was retained in the heart and liver within 24 h.en_US
dc.description.sponsorshipEge University Scientific Research FundEge University [2009 NBE 014]en_US
dc.description.sponsorshipAuthors thank to Ege University Scientific Research Fund for the financial support with the Project Number 2009 NBE 014 and also thank to the contributions of Metis Biotechnology Ltd in animal imaging studies.en_US
dc.identifier.doi10.1515/ract-2013-2152
dc.identifier.endpage859en_US
dc.identifier.issn0033-8230
dc.identifier.issn0033-8230en_US
dc.identifier.issue9en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage849en_US
dc.identifier.urihttps://doi.org/10.1515/ract-2013-2152
dc.identifier.urihttps://hdl.handle.net/11454/49822
dc.identifier.volume102en_US
dc.identifier.wosWOS:000342730700010en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofRadiochimica Actaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCdSe/CdS quantum dotsen_US
dc.subjectradiolabeled nanoparticlesen_US
dc.subjectradioiodinationen_US
dc.subjectSambucus nigra agglutinin (SNA) lectinen_US
dc.subjectCaco-2en_US
dc.subjectMCF-7en_US
dc.subjectA-549en_US
dc.subjectcancer cellsen_US
dc.subjectmolecular imagingen_US
dc.subjectNew Zealand rabbitsen_US
dc.subjectBalb C miceen_US
dc.titleRadioiodine labeled CdSe/CdS quantum dots: Lectin targeted dual probesen_US
dc.typeArticleen_US

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