Neuromuscular effect of pipecuronium bromide
Küçük Resim Yok
Tarih
1994
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
'Onset of action', 'duration of action', 'recovery index' and 'reversibility with anticholinesterases' of pipecuronium bromide, a new muscle relaxant, were studied on 24 cases with ASA physical status 1 who received thiopental, N2O-O2 and isoflurane anesthesia. Neuromuscular function was monitored with mechanomyography (MMG) and train-of-four (TOF) stimulation model of 3 groups each containing 8 patients; group I was given 70 µg.kg-1; group II 85 µg.kg-1 and group III 100 µg.kg-1 pipecuronium bromide. There was no statistically significant difference between 3 groups on the basis of 'onset of action' which was found to be 2.7 min; 2.8 min, 2.2 min in the groups I, II and III, respectively (p > 0.05). Statistically significant difference between groups on the basis of 'duration of action' which was found to be 73.3 min in the group I, 77.1 min in the group II and 104.8 min in the group III, was recognized to be due to the significantly longer action of the agent on 100 µg.kg-1 dose group (p < 0.01). 'Recovery index' and % T1 values before and 2, 5, 8 and 10 min after decurarization showed no statistically significant difference between groups (p > 0.05). TOF ratios before decurarization which were found to be 10.1% in the group I, 20.3% in the group II and 10.0% in the group III showed statistically significant difference between groups (p < 0.01). According to data obtained from this study, it was concluded that: by using the suggested doses for clinical practice, action of pipecuronium bromide, which started in 2-3 min and lasted 73-105 min, might be easily reversed by anticholinesterases (reversal time being dose dependent) and might be preferred for surgical procedures especially requiring long periods of muscle relaxation.
Açıklama
Anahtar Kelimeler
Neuromuscular effect, Pipecuronium
Kaynak
Turk Anesteziyoloji ve Reanimasyon
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
22
Sayı
1
