The effect of granulocyte colony-stimulating factor on mortality rate in experimental sepsis [DENEYSEL SEPSISTE GRANULOSIT KOLONI-STIMULAN FAKTOR UYGULANMESININ MORTALITEYE ETKISI]

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dc.contributor.authorAyanoglu H.O.
dc.contributor.authorCanturk Z.
dc.contributor.authorKoca U.
dc.contributor.authorMoral A.R.
dc.date.accessioned2019-10-27T00:32:35Z
dc.date.available2019-10-27T00:32:35Z
dc.date.issued1996
dc.departmentEge Üniversitesien_US
dc.description.abstractNeutrophils have an important role in the initial phase of host defense. One of the growth factors, Granulocyte Colony-Stimulating Factor (G-CSF) enhances neutrophil counts and functional capacity. The aim of this study was to investigate the effect of recombinant human (rh) G-CSF on mortality rate in an experimental sepsis model performed by 'Cecal Ligation and Puncture' (CLP) in rats. Totally 48 rats were separated into 3 groups and SF alone (Group I) or antibiotic alone (Group II) or antibiotic + G-CSF (Group III) were injected 24 hours before CLP procedure. The calculated absolute neutrophil counts of the blood samples taken by cardiac puncture at the 24th hour after CLP were significantly higher in Group III when compared to the other groups and the control samples which were taken before the study period (p<0.05). At the end of the seven days observation period the mortality rate of antibiotic + G-CSF injected Group III was 26.7 % and was significantly lower than the other two groups (p<0.05). No significant difference was observed in between the mortality rates of 75 % in Group I and 70 % in Group II (p>0.05). Further investigations are necessary for G-CSF to be used widely in clinical pratice.en_US
dc.identifier.endpage439en_US
dc.identifier.issn1016-5150
dc.identifier.issn1016-5150en_US
dc.identifier.issue10en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage436en_US
dc.identifier.urihttps://hdl.handle.net/11454/23834
dc.identifier.volume24en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofTurk Anesteziyoloji ve Reanimasyonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCecal ligation and punctureen_US
dc.subjectG-CSFen_US
dc.subjectMortality rateen_US
dc.subjectRaten_US
dc.titleThe effect of granulocyte colony-stimulating factor on mortality rate in experimental sepsis [DENEYSEL SEPSISTE GRANULOSIT KOLONI-STIMULAN FAKTOR UYGULANMESININ MORTALITEYE ETKISI]en_US
dc.typeArticleen_US

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