Nano-immunotherapeutic strategies for targeted RNA delivery: Emphasizing the role of monocyte/macrophages as nanovehicles to treat glioblastoma multiforme

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dc.authoridAboudzadeh, M. Ali/0000-0001-8829-8072
dc.authoridBilal, Muhammad/0000-0001-5388-3183
dc.authoridSargazi, Saman/0000-0002-2255-5977
dc.authoridG, Venkat Kumar/0000-0001-6137-774X
dc.authorscopusid57554745300
dc.authorscopusid57201953828
dc.authorscopusid57203967303
dc.authorscopusid57195215587
dc.authorscopusid36599143100
dc.authorscopusid57222095969
dc.authorscopusid37664422200
dc.authorwosidAboudzadeh, M. Ali/B-3131-2016
dc.authorwosidBilal, Muhammad/AAH-6461-2020
dc.authorwosidSargazi, Saman/Y-7793-2019
dc.authorwosidER, Simge/HGU-2032-2022
dc.contributor.authorManicum, Amanda-Lee Ezra
dc.contributor.authorSargazi, Saman
dc.contributor.authorRazzaq, Sobia
dc.contributor.authorKumar, Govindarajan Venkat
dc.contributor.authorRahdar, Abbas
dc.contributor.authorEr, Simge
dc.contributor.authorUl Ain, Qurrat
dc.date.accessioned2023-01-12T19:55:14Z
dc.date.available2023-01-12T19:55:14Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractGlioblastoma multiforme (GBM) is considered the most aggressive and heterogeneous type of brain malignancy. The substantial invasion of the central nervous system parenchyma is a typical hallmark of all grades of glioma. To improve tumor localization and prevent unanticipated toxicity, anti-tumor drug delivery mechanisms must be upgraded in parallel with pharmacotherapeutics. Monocytes can easily pass the blood-brain barrier, and thus, drugs with difficulty entering the brain can be loaded into monocytes, resulting in the treatment of brain cancers. RNA as a natural and biocompatible polymer has many advantages for biomedical applications, and RNA-based therapies can provide regulated biological functions by highly selective and controlling means. In this context, macrophages are excellent carriers for distributing RNA-based treatments. However, developing an efficient macrophage-targeted RNA delivery has remained challenging. Several approaches have been introduced in the last decade to efficiently deliver RNA-based therapy via macrophages to treat GBM and inflammatory conditions. This review summarizes the most suitable nano-carrier systems to deliver RNA into immunocytes; also, different methods of synthesizing RNA-loaded nanoparticles and their application, with an emphasis on targeting GBM, are discussed. Furthermore, it focuses specifically on the stability of such nanoformulations and the effect of targeting moieties and adjuvants in determining the worth of the aroused immune response. Finally, the critical aspects of delivering RNA-lipid hybrid nanoparticles (LNPs) via oral, systemic, and local routes are highlighted. We hope that these findings will pave the way for more effective treatment of solid tumors, such as GBM, in the future.en_US
dc.identifier.doi10.1016/j.jddst.2022.103288
dc.identifier.issn1773-2247
dc.identifier.issn2588-8943
dc.identifier.issn1773-2247en_US
dc.identifier.issn2588-8943en_US
dc.identifier.scopus2-s2.0-85127268771en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.jddst.2022.103288
dc.identifier.urihttps://hdl.handle.net/11454/76640
dc.identifier.volume71en_US
dc.identifier.wosWOS:000792125300005en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal Of Drug Delivery Science And Technologyen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGlioblastoma multiformeen_US
dc.subjectImmunotherapyen_US
dc.subjectNanotechnologyen_US
dc.subjectTargeted therapyen_US
dc.subjectTumor-Associated Macrophagesen_US
dc.subjectSolid Lipid Nanoparticlesen_US
dc.subjectIron-Oxide Nanoparticlesen_US
dc.subjectMessenger-Rnaen_US
dc.subjectDrug-Deliveryen_US
dc.subjectIn-Vivoen_US
dc.subjectSirna Deliveryen_US
dc.subjectCirculating Monocytesen_US
dc.subjectM(6)A Modificationen_US
dc.subjectMediated Deliveryen_US
dc.titleNano-immunotherapeutic strategies for targeted RNA delivery: Emphasizing the role of monocyte/macrophages as nanovehicles to treat glioblastoma multiformeen_US
dc.typeReviewen_US

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