Histopathological and Immunohistochemical Features of 32 Cases of Splenic B-Cell Lymphoma and Leukemia

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dc.contributor.authorDoger, Furuzan Kacar
dc.contributor.authorHekimgil, Mine
dc.contributor.authorErtan, Yesim
dc.contributor.authorSarsik, Banu
dc.contributor.authorSoydan, Saliha
dc.contributor.authorNese, Nalan
dc.date.accessioned2019-10-27T21:19:36Z
dc.date.available2019-10-27T21:19:36Z
dc.date.issued2009
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: Leukemias and non-Hodgkin lymphomas commonly involve the spleen or originate primarily in the spleen and then spread to other sites. Material and Methods: In this retrospective study, we examined the histopathological and immunohistochemical characteristics of 32 cases of primary or secondary splenic B-cell lymphoma and leukemia, in which the diagnosis was established according to the World Health Organization (WHO) classification. The immunohistochemical panel included ALK-1, BCL-2, BCL-6, CD3, CD5, CD10, CD20, CD21, CD23, CD30, CD43, cyclin D1, Ki-67, and TRAP. Results: There was no other nodal or extranodal disease involvement in the majority of patients diagnosed with lymphoma at the time of presentation, while cases of leukemia had undergone splenectomy for palliative purposes. The diagnoses were as follows: 11 cases of hairy cell leukemia (HCL, 34.4%), 8 cases of splenic marginal zone lymphoma (SMZL, 25%), 8 cases of diffuse large B-cell lymphoma (DLBCL, 25%) including 1 T-cell-rich B-cell lymphoma (TCRBCL), 4 cases of mantle cell lymphoma (MCL, 12.5%), and 1 prolymphocytic leukemia (PLL, 3.1%). Conclusion: Overall assessment of spleen, liver, bone marrow, and lymph node examinations and a detailed correlation of the histopathological and immunohistochemical features with the clinical findings are very helpful and usually lead to the final diagnosis in most cases of primary or secondary splenic B-cell lymphoma and leukemia.en_US
dc.identifier.endpage1472en_US
dc.identifier.issn1300-0292
dc.identifier.issn2146-9040
dc.identifier.issn1300-0292en_US
dc.identifier.issn2146-9040en_US
dc.identifier.issue6en_US
dc.identifier.startpage1463en_US
dc.identifier.urihttps://hdl.handle.net/11454/44171
dc.identifier.volume29en_US
dc.identifier.wosWOS:000273915500017en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherOrtadogu Ad Pres & Publ Coen_US
dc.relation.ispartofTurkiye Klinikleri Tip Bilimleri Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLymphoma, non-Hodgkinen_US
dc.subjectsplenic neoplasmsen_US
dc.subjectleukemia, B-cellen_US
dc.titleHistopathological and Immunohistochemical Features of 32 Cases of Splenic B-Cell Lymphoma and Leukemiaen_US
dc.typeArticleen_US

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