Lymphovascular space invasion and positive peritoneal cytology are independent prognostic factors for lymph node metastasis and recurrence in endometrial cancer

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dc.contributor.authorYildirim, N.
dc.contributor.authorBilgi, A.
dc.contributor.authorGokulu, S. G.
dc.contributor.authorAkman, L.
dc.contributor.authorZekioglu, O.
dc.contributor.authorSerin, G.
dc.contributor.authorOzdemir, N.
dc.contributor.authorAlanyali, S.
dc.contributor.authorOzsaran, Z.
dc.contributor.authorOzsaran, A. A.
dc.contributor.authorTerek, M. C.
dc.date.accessioned2019-10-27T10:44:27Z
dc.date.available2019-10-27T10:44:27Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractAim: The aim is to identify the risk factors for recurrence and lymphatic metastasis of endometrial cancer. Materials and Methods: Patients who were operated primarily for endometrial cancer between 2010-2016 were included. Parameters such as stage, grade, histology, depth of invasion, cytology status, lymphovascular space invasion (LVSI), and tumor size were recorded. Univariate and multivariate logistic regression models were used to identify pathological predictors of lymphatic dissemination and recurrence. Results: A total of 278 patients were evaluated. Mean age was 60. 80% were Stage I, 10% were Stage III, and 4% were Stage IV, and 36.7% of patients had LVSI. Lymphadenectomy was performed in 56% of patients and lymphatic metastasis was observed in 7.1% of patients. In 13 patients, recurrence occurred; seven were loco-regional and six were distant. Three patients who had recurrence (3/13) were in early stage. With multivariate analysis, LVSI [OR = 8.826;1.874-41.576 (95%CI),p = 0.006] and positive cytology [OR = 9.503;1.811-49.876 (95%CI),p = 0.008] were independent factors for recurrence in endometrial cancer. Additionally, for lymphatic metastasis. LVSI [OR = 6.195;1.258-30.506 (95%CI), p = 0.025] and positive cytology [OR = 14.258; 2.330-87.247 (95%CI), p = 0.004] were found as significant risk factors. Conclusion: LVSI and positive cytology are significant risk factors for lymphatic metastasis and recurrence in endometrial cancer. Patients who had these risk factors should be followed-up more cautiously in terms of recurrence.en_US
dc.identifier.doi10.12892/ejgo4539.2018
dc.identifier.endpage983en_US
dc.identifier.issn0392-2936
dc.identifier.issn0392-2936en_US
dc.identifier.issue6en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage977en_US
dc.identifier.urihttps://doi.org/10.12892/ejgo4539.2018
dc.identifier.urihttps://hdl.handle.net/11454/30980
dc.identifier.volume39en_US
dc.identifier.wosWOS:000452166200022en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherI R O G Canada, Incen_US
dc.relation.ispartofEuropean Journal of Gynaecological Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndometrial canceren_US
dc.subjectLymph nodeen_US
dc.subjectLymphovascular space invasionen_US
dc.subjectPeritoneal cytologyen_US
dc.subjectRecurrenceen_US
dc.titleLymphovascular space invasion and positive peritoneal cytology are independent prognostic factors for lymph node metastasis and recurrence in endometrial canceren_US
dc.typeArticleen_US

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