Synthesis, characterization and biodistribution of 99mTc-Bioquin-HMPAO (99mTc-BH) as a novel brain imaging agent

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dc.contributor.authorYurt Kilcar A.
dc.contributor.authorBiber Muftuler F.Z.
dc.contributor.authorEnginar H.
dc.contributor.authorTekin V.
dc.contributor.authorMedine E.I.
dc.contributor.authorUnak P.
dc.date.accessioned2019-10-27T08:22:22Z
dc.date.available2019-10-27T08:22:22Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractRecently, the development of novel brain imaging agents has aroused much interest thanks to limited number of brain cancer or diseases diagnosis agents. It is aimed to synthesize a novel brain imaging agent including a promise for further studies on AD diagnosis potential and investigate its bioaffinity with biodistribution studies on healthy Balb/c mice. A novel radiolabeled agent was synthesized and characterized. Quality control of 99mTc-BH was performed utilizing solvent extraction and chromatographic (Radio TLC and Radio HPLC) methods. Bioaffinity of the 99mTc-BH was investigated on male Balb/c mice at various time points (5, 30, 60, 120 min post-injection). Paper electrophoresis showed that 99mTc-BH has a neutral structure. Radiochemical purity of 99mTc-BH was over 95 % with appropriate stability for imaging period. Selected brain regions have uptakes over 4 % ID/g following intravenous injection. Hippocampus has uptake approximately 10 % ID/g. 99mTc-BH has shown brain uptake, so it may prove to be valuable for brain imaging as a novel technetium-labeled agent. Further investigations with AD animal model are our on going effort to show that this agent has AD diagnosis potential. © 2014, Akadémiai Kiadó, Budapest, Hungary.en_US
dc.description.sponsorship2011 NBE 003en_US
dc.description.sponsorshipAcknowledgments This work is supported by Ege University Research Fund (contract no 2011 NBE 003). The authors thank to Eser Uc¸ar, Cansu Uzaras, Kadir Arı and Barıs¸ Yılmaz for the technical assistance during the animal experiments. --en_US
dc.identifier.doi10.1007/s10967-014-3175-1
dc.identifier.endpage573en_US
dc.identifier.issn0236-5731
dc.identifier.issn0236-5731en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage563en_US
dc.identifier.urihttps://doi.org/10.1007/s10967-014-3175-1
dc.identifier.urihttps://hdl.handle.net/11454/26237
dc.identifier.volume302en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKluwer Academic Publishersen_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject99mTcen_US
dc.subjectBioquinen_US
dc.subjectBrain imagingen_US
dc.subjectHMPAOen_US
dc.titleSynthesis, characterization and biodistribution of 99mTc-Bioquin-HMPAO (99mTc-BH) as a novel brain imaging agenten_US
dc.typeArticleen_US

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