Salivary inflammatory burden in pre- and postmenopausal women: Associations with body mass index, patient-reported health, serum cytokines, and periodontal parameters

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dc.authorscopusid57204391655
dc.authorscopusid14059543900
dc.authorscopusid7003325190
dc.authorscopusid25031084600
dc.authorscopusid57267616700
dc.authorscopusid35734773300
dc.authorscopusid6701658370
dc.contributor.authorYakar, N.
dc.contributor.authorBostanci, N.
dc.contributor.authorÖzdemir, G.
dc.contributor.authorAtmaca, H.
dc.contributor.authorTüredi, A.
dc.contributor.authorŞahin, Ç.
dc.contributor.authorKöse, T.
dc.date.accessioned2024-08-25T18:31:51Z
dc.date.available2024-08-25T18:31:51Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground: The decline of estrogen levels during menopause impacts weight, mood, and overall health, both orally and systemically. This study assessed salivary levels of tumor necrosis factor alpha (TNF-?), interleukin-6 (IL-6), IL-10, and IL-7 in postmenopausal (PMW) and regularly menstruating premenopausal (RMPW) women, while considering serum cytokine levels, body mass index (BMI), periodontal health, and self-reported physical and emotional well-being. Methods: In this study, 75 PMW and 71 RMPW were included. Clinical and periodontal parameters were evaluated, and perceived health was assessed with the Women's Health Questionnaire (WHQ). Cytokine levels in both saliva and serum were quantified by enzyme-linked immunosorbent assay (ELISA). Covariate evaluations of salivary cytokines were conducted using hierarchical linear regression modeling. Results: Cytokines were detectable in saliva from 71 PMW and 67 RMPW. In the initial unadjusted model, IL-7, IL-10, and TNF-? exibited significant differences between RMPW and PMW. However, these differences became non-significant (p > 0.05) in the final model after adjusting for age, which implies a negligible effect of the investigated covariates on salivary cytokine levels when age was considered. Lower levels of IL-6 in PMW, which initially showed no significant difference, became borderline (p = 0.054) in the final model after adjusting for age. Conclusions: After adjusting for multiple factors, no significant difference was found in the salivary levels of the investigated cytokines between RMPW and PMW. Factors such as BMI, perceived health, serum cytokine levels, and periodontal parameters seem to minimally influence these levels in PMW. However, age may be a stronger confounding factor. © 2023 The Authors. Journal of Periodontology published by Wiley Periodicals LLC on behalf of American Academy of Periodontology.en_US
dc.description.sponsorshipTOA 2020?21085en_US
dc.description.sponsorshipThis study is supported by Ege University Scientific Research Foundation with grant number: TOA 2020?21085.en_US
dc.identifier.doi10.1002/JPER.23-0124
dc.identifier.issn0022-3492
dc.identifier.scopus2-s2.0-85174232437en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1002/JPER.23-0124
dc.identifier.urihttps://hdl.handle.net/11454/100047
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Incen_US
dc.relation.ispartofJournal of Periodontologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240825_Gen_US
dc.subjectcytokinesen_US
dc.subjectpostmenopauseen_US
dc.subjectpremenopauseen_US
dc.subjectsalivaen_US
dc.titleSalivary inflammatory burden in pre- and postmenopausal women: Associations with body mass index, patient-reported health, serum cytokines, and periodontal parametersen_US
dc.typeArticleen_US

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