COVID-19 Infection, Vaccination, and Antibody Levels: Investigating Correlations through a Cohort Study
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Multidisciplinary Digital Publishing Institute (MDPI)
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: The objective of this study was to explore the potential correlation between COVID-19 infection or vaccination and levels of anti-nucleocapsid (anti-N) and anti-spike (anti-S) antibodies. Methods: Among 6050 healthcare workers at the Ege University Hospital, a cohort study with 162 participants divided into three arms with 54 participants each was conducted. The three groups were selected as follows: those diagnosed with COVID-19 and not vaccinated (group 1), those diagnosed with COVID-19 and subsequently vaccinated with CoronaVac (group 2), and those not diagnosed with COVID-19 but vaccinated with two doses of CoronaVac (group 3). Antibody levels measured at the sixth month of follow-up were defined as the primary outcome. Results: At the sixth month, all serum samples tested positive for anti-S. Anti-S levels were found to be significantly higher in group 2 than in the other groups (p < 0.001). There were no differences in antibody levels between groups 1 and 3 (p = 0.080). Average antibody levels were found to be lower in office workers and males. Anti-N antibodies were found to be positive in 85.1% of subjects at the sixth month. In group 2, anti-N antibodies were detected in all samples at the sixth month. Anti-N antibody levels were not significantly different between groups 1 and 2 (p = 0.165). Groups 1 and 2 had significantly higher antibody levels than group 3 (p < 0.001). Conclusions: Vaccination or infection provide protection for at least 6 months. Those who have previously been diagnosed with COVID-19 do not need to be vaccinated in the early period before their antibody levels decrease. © 2023 by the authors.
Açıklama
Anahtar Kelimeler
anti-nucleocapsid, anti-spike, healthcare worker, SARS-CoV-2, coronavac, elecsys, immunoglobulin G antibody, nucleocapsid protein, SARS-CoV-2 antibody, adult, antibody blood level, antibody detection, antibody response, Article, cohort analysis, coronavirus disease 2019, employment, female, follow up, health care personnel, human, major clinical study, male, middle aged, nasopharyngeal swab, occupation, office worker, reverse transcription polymerase chain reaction, Severe acute respiratory syndrome coronavirus 2, vaccination
Kaynak
Vaccines
WoS Q Değeri
Scopus Q Değeri
Q1
Cilt
11
Sayı
7
