Mid-Regional Proadrenomedullin Levels in Primary Immunodeficiencies Complicated with Pulmonary Manifestations

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dc.authoridKaraca, Neslihan/0000-0002-2202-7082
dc.authoridAzarsiz, Elif/0000-0002-2887-7029
dc.authorscopusid6505770201
dc.authorscopusid15762370000
dc.authorscopusid7006914574
dc.authorwosidKaraca, Neslihan/AAW-1924-2020
dc.authorwosidAzarsiz, Elif/J-2034-2015
dc.contributor.authorAzarsiz, Elif
dc.contributor.authorKaraca, Neslihan
dc.contributor.authorKutukculer, Necil
dc.date.accessioned2023-01-12T19:51:32Z
dc.date.available2023-01-12T19:51:32Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractThe development of lower respiratory complications in children with primary immunodeficiencies characterized by recurrent infections significantly contributes to morbidity and mortality. This is clinically more important and specific in the evaluation of prognosis. The inflammatory response that develops throughout the clinical process can cause the release of several biomarkers. This study aimed to evaluate the inflammatory biomarker mid-regional pro-adrenomedullin (MR-proADM) levels by distribution of lower respiratory tract complications. Plasma MR-proADM levels were measured in children with (n = 52) and without (n = 103) lower respiratory tract complications. The complicated group was also evaluated as infective and non-infective groups. The median MR-proADM levels were higher in the complicated cases (p = 0.175). It was 205.5 (73.4- 562.6) ng/L in the infective group while it was 96.1 (26.1-43.3) ng/L in the non-infective group and the difference between the two groups was statistically significant (p = 0.003). The predictive value of MR-proADM (AUC = 0.749, p = 0.003) was statistically significant compared to CRP (AUC = 0.330, p = 0.040) and SAA (AUC = 0.261, p = 0.004) in the infective group. This study evidences that the MR-proADM levels are higher in PID cases with infective pulmonary complications. Among other markers, MR-proADM appears to be a particularly good predictive inflammation marker for these children.en_US
dc.description.sponsorshipEge University Scientific Research Projects Coordination Unit [TKB-2019-20570]en_US
dc.description.sponsorshipWe thank to Ege University Scientific Research Projects Coordination Unit (Career Start Support Project Number: TKB-2019-20570).en_US
dc.identifier.doi10.1007/s12291-022-01061-9
dc.identifier.issn0970-1915
dc.identifier.issn0974-0422
dc.identifier.issn0970-1915en_US
dc.identifier.issn0974-0422en_US
dc.identifier.scopus2-s2.0-85137759167en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1007/s12291-022-01061-9
dc.identifier.urihttps://hdl.handle.net/11454/76289
dc.identifier.wosWOS:000852135400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer Indiaen_US
dc.relation.ispartofIndian Journal Of Clinical Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdrenomedullinen_US
dc.subjectBiomarkersen_US
dc.subjectChildrenen_US
dc.subjectInflammationen_US
dc.subjectRespiratory tract infectionsen_US
dc.subjectCommunity-Acquired Pneumoniaen_US
dc.subjectPro-Adrenomedullinen_US
dc.subjectPrognostic Markeren_US
dc.subjectPredictionen_US
dc.subjectDiseasesen_US
dc.subjectInfectionsen_US
dc.subjectBiomarkersen_US
dc.subjectManagementen_US
dc.titleMid-Regional Proadrenomedullin Levels in Primary Immunodeficiencies Complicated with Pulmonary Manifestationsen_US
dc.typeArticleen_US

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