Effects of Embryonic Neural Stem Cell Transplantation on DNA Damage in the Brain and Spinal Cord Following Spinal Cord Injury

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dc.contributor.authorDagci, T.
dc.contributor.authorKonyalioglu, S.
dc.contributor.authorKeser, A.
dc.contributor.authorKayalioglu, G.
dc.date.accessioned2019-10-27T21:19:24Z
dc.date.available2019-10-27T21:19:24Z
dc.date.issued2009
dc.departmentEge Üniversitesien_US
dc.description.abstractEmbryonic neural stem cell (ENSC) transplantation is used experimentally for the improvement of spinal cord repair following spinal cord injury (SCI). However, the effects of such intervention on oxidative stress and cell death remain unknown. We used in vivo Comet assay in the acute and chronic SCI groups compared with the SCI+ENSC transplantation groups of experimental rats in order to evaluate DNA damage in the spinal cord. Chronic SCI resulted in the generation of oxidative DNA damage in the spinal cord brain and kidneys, as indicated by high Comet assay parameters, including the percentage of DNA in the tail (T%, or TD), tail moment (TM), and tail length (TL). The DNA damage levels significantly decreased after ENSC transplantation in the spinal cords of acute and chronic SCI groups within the lesion site and rostrally and caudally to the injury, and in the brains and kidneys of the chronic SCI group. Thus, ENSC transplantation is found to be an effective tool for limitation of DNA damage following spinal cord injury.en_US
dc.identifier.doi10.1007/s11062-010-9120-1
dc.identifier.endpage415en_US
dc.identifier.issn0090-2977
dc.identifier.issn1573-9007
dc.identifier.issn0090-2977en_US
dc.identifier.issn1573-9007en_US
dc.identifier.issue6en_US
dc.identifier.startpage409en_US
dc.identifier.urihttps://doi.org/10.1007/s11062-010-9120-1
dc.identifier.urihttps://hdl.handle.net/11454/44140
dc.identifier.volume41en_US
dc.identifier.wosWOS:000276921400006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofNeurophysiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectspinal cord injuryen_US
dc.subjectstem cellsen_US
dc.subjectDNA damageen_US
dc.subjectComet assayen_US
dc.titleEffects of Embryonic Neural Stem Cell Transplantation on DNA Damage in the Brain and Spinal Cord Following Spinal Cord Injuryen_US
dc.typeArticleen_US

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