Variation in the Oxytocin Receptor Gene Is Associated With Social Cognition and ADHD

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dc.contributor.authorKalyoncu, Tugba
dc.contributor.authorOzbaran, Burcu
dc.contributor.authorKose, Sezen
dc.contributor.authorOnay, Huseyin
dc.date.accessioned2019-10-27T09:44:40Z
dc.date.available2019-10-27T09:44:40Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: Children with ADHD show substantial deficits in social cognitive abilities. Oxytocin, mediated through its specific receptor (OXTR), is involved in the regulation of social behavior and social cognition. Method: The entire coding sequence of the human OXT and OXTR genes were sequenced to identify mutations and single nucleotide polymorphisms (SNPs) in 151 children with ADHD (ADHD-combined, n = 51; inattentive subtype, n = 50; ADHD-C plus conduct disorder [CD], n = 50; 11-18 years) and 100 healthy controls. Results: We examined the association of three detected SNPs of OXTR with social cognition deficits. A significant association was shown between the children with ADHD and children with CT/TT genotypes of rs4686302 (chi(2) = 3.695; p = .037). ADHD children with CT/TT genotype for the OXTR rs4686302 performed significantly lower on the facial emotion recognition task than those with CC genotype. Conclusion: OXTR rs4686302 polymorphism was shown to be a genetic marker in social cognition deficits in ADHD children.en_US
dc.identifier.doi10.1177/1087054717706757
dc.identifier.endpage711en_US
dc.identifier.issn1087-0547
dc.identifier.issn1557-1246
dc.identifier.issn1087-0547en_US
dc.identifier.issn1557-1246en_US
dc.identifier.issue7en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage702en_US
dc.identifier.urihttps://doi.org/10.1177/1087054717706757
dc.identifier.urihttps://hdl.handle.net/11454/29032
dc.identifier.volume23en_US
dc.identifier.wosWOS:000465015800006en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofJournal of Attention Disordersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectsocial cognitionen_US
dc.subjectoxytocin geneen_US
dc.subjectoxytocin receptor geneen_US
dc.subjectpolymorphismen_US
dc.subjectADHD subtypesen_US
dc.titleVariation in the Oxytocin Receptor Gene Is Associated With Social Cognition and ADHDen_US
dc.typeArticleen_US

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