A Case of Plurihormonal Pituitary Giant Macroadenoma

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dc.authorscopusid56548536700
dc.authorscopusid26656445700
dc.authorscopusid12753401700
dc.authorscopusid24824386400
dc.authorscopusid23994350000
dc.authorscopusid23025741400
dc.contributor.authorOzisik, Hatice
dc.contributor.authorYurekli, Banu Sarer
dc.contributor.authorErtan, Yesim
dc.contributor.authorEraslan, Cenk
dc.contributor.authorOzgiray, Erkin
dc.contributor.authorSaygili, Fusun
dc.date.accessioned2023-01-12T20:12:26Z
dc.date.available2023-01-12T20:12:26Z
dc.date.issued2021
dc.departmentN/A/Departmenten_US
dc.description.abstractWe would like to draw the attention of the readers to Pit-1 positive giant macroadenomas in this work. A 62-year-old male patient was admitted to the hospital due to his vision loss and blurred vision in the left eye. His pituitary magnetic resonance imaging revealed the presence of a diffuse and homogeneous mass lesion originating from the pituitary gland having grade 4 invasion into the bilateral cavernous sinus and eroding the base of the sella. He consulted our department before his operation in 2016. Laboratory examination revealed that pituitary hormone levels were within normal ranges while the testosterone level [total testosterone 0.27 ng/mL (2.8-8)] was low. Pathological findings revealed a pituitary adenoma that displayed focal immunoreactivity to thyrotrophin, growth hormone, and prolactin. While the main prevalence and the basic mechanism of plurihormonal pituitary adenomas are not clear, one of the hypotheses is based on the role of divergent transcription factors such as Pit-1. According to this condition, we should perform a complete biochemical and histologic evaluation in patients with pituitary adenomas.en_US
dc.identifier.doi10.25179/tjem.2020-78997
dc.identifier.endpage231en_US
dc.identifier.issn1301-2193
dc.identifier.issn1301-2193en_US
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85110906671en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage227en_US
dc.identifier.urihttps://doi.org/10.25179/tjem.2020-78997
dc.identifier.urihttps://hdl.handle.net/11454/78303
dc.identifier.volume25en_US
dc.identifier.wosWOS:000663367200012en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofTurkish Journal Of Endocrinology And Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPlurihormonal adenomaen_US
dc.subjectpituitary diseasesen_US
dc.subjectgrowth hormone-secreting pituitary adenomaen_US
dc.subjectlactotrophsen_US
dc.subjectPit-1 Gene-Expressionen_US
dc.subjectGrowth-Hormoneen_US
dc.subjectSingle-Centeren_US
dc.subjectAdenomasen_US
dc.subjectSilenten_US
dc.subjectClassificationen_US
dc.subjectThyrotropinen_US
dc.subjectOutcomesen_US
dc.subjectTumorsen_US
dc.titleA Case of Plurihormonal Pituitary Giant Macroadenomaen_US
dc.title.alternativePlurihormonal hipofizer dev makroadenomu olan olgu sunumuen_US
dc.typeArticleen_US

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