The Synergistic Effect of Fotemustine and Genistein on Expressions of p53, EGFR and COX-2 Genes in Human Glioblastoma Multiforme Cell Line

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dc.contributor.authorAvci, Cigir Biray
dc.contributor.authorDodurga, Yavuz
dc.contributor.authorOktar, Nezih
dc.contributor.authorSusluer, Sunde Yilmaz
dc.contributor.authorSigva, Zeynep Ozlem Dogan
dc.contributor.authorGunduz, Cumhur
dc.date.accessioned2019-10-27T21:33:52Z
dc.date.available2019-10-27T21:33:52Z
dc.date.issued2012
dc.departmentEge Üniversitesien_US
dc.description.abstractGBM is the most common primary malignant neoplasm of the central nervous system in adults. Fotemustine (FTM) is a cytotoxic alkylating agent and a lipophilic chloroethylnitrosourea derivative. Its mechanism of action consists mainly in inducing DNA strand breaks and cross-linking. Genistein, one of the soy-derived isoflavones, exerts its anticancer properties via several mechanisms, including inhibition of tyrosine phosphorylation, weak estrogenic and anti-estrogenic properties, as an antioxidant, inhibition of topoisomerase II, inhibition of angiogenesis, and induction of cell differentiation in a number of human tumors. We aimed to investigate the anti-proliferative synergistic effect of genistein with fotemustine on human glioblastoma multiforme U87-MG cells. This study was also designed to answer the following question: Do the p53, EGFR, COX-2 genes' expression patterns differ in treatment of these both drugs alone and in combination?en_US
dc.identifier.endpage517en_US
dc.identifier.issn1302-1664
dc.identifier.issn1302-1664en_US
dc.identifier.issue3en_US
dc.identifier.startpage510en_US
dc.identifier.urihttps://hdl.handle.net/11454/45452
dc.identifier.volume29en_US
dc.identifier.wosWOS:000309218800008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherJournal Neurological Sciencesen_US
dc.relation.ispartofJournal of Neurological Sciences-Turkishen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFotemustineen_US
dc.subjectGenisteinen_US
dc.subjectU-87MGen_US
dc.subjectp53en_US
dc.subjectEGFRen_US
dc.subjectCOX-2en_US
dc.titleThe Synergistic Effect of Fotemustine and Genistein on Expressions of p53, EGFR and COX-2 Genes in Human Glioblastoma Multiforme Cell Lineen_US
dc.typeArticleen_US

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