The interaction of ionizing radiation and silicone medical implants: Evaluation of the effects on radiotherapy dose distribution and alteration in the physical properties of the silicone

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dc.authorscopusid55608300300
dc.authorscopusid47561912700
dc.authorscopusid6603635579
dc.contributor.authorHoca, Sinan
dc.contributor.authorOlacak, Nezahat
dc.contributor.authorAnacak, Yavuz
dc.date.accessioned2024-08-25T18:37:12Z
dc.date.available2024-08-25T18:37:12Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractSilicone prostheses are implanted inside the human body for medical aesthetics and reconstructive reasons. The presence of a silicone prosthesis around the radiotherapy volume may alter radiotherapy dose distribution and cause overdose and underdose areas in the target volumes and organs at risk. The interaction of silicone with radiation may be two-sided since high dose radiation may cause alteration of the physical and chemical prop-erties of silicone which further contributes to changes in the dose distribution. The aim of this study was to evaluate the changes in radiation dose distribution caused by silicone and the effects of irradiation on silicone elastomer prostheses. A special set-up was prepared in the water phantom to obtain depth dose and profile data for non-irradiated silicone blocks prior to the irradiation schedule. Entrance and exit doses between silicone and water medium were measured using thermoluminescence dosimetry (TLD). Hardness tests on silicone blocks were performed by using Tronic Shore A Durometer device and density tests were performed by using Scaltec density determination instrument. Irradiation of the silicone was performed using a linear accelerator with 6 MV and 10 MV photon energies, 2 Gy daily fractions in 5 weeks were delivered to a total dose of 50 Gy. After the completion of 5 weeks schedule depth doses, profile measurements, entrance-exit doses and density-hardness tests were repeated. The non-irradiated silicone blocks affected the depth dose distribution in the water phantom to a maximum dose reduction of 1.5% for 6 MV and 1.6% for 10 MV. After the 5 weeks of irradiation, depth dose reduction increased to 2.5% for 6 MV and 2.0% for 10 MV. Silicone blocks affected the dose profile as well: maximum dose difference was 2.7% for 6 MV and 2.4% for 10 MV for non-irradiated silicone, 2.6% for 6 MV, and 2% for 10 MV after 50 Gy. However, these changes in depth dose and profile data in non-irradiated and irradiated silicone were not significant. There was up to an 8% dose decrease in exit doses beyond the silicone with the use of a single direct irradiation field, which is expected to be reduced with multi-field radiotherapy. The physical properties of the non-irradiated and irradiated silicone measured by hardness and density tests were similar. The only physical difference we noted was the discoloration of silicone to a yellowish color. According to our results silicone elastomer prostheses did not have significant effects on dose distribution after 50 Gy irradiation, and radiation doses used for radiotherapy did not alter the physical properties of silicone blocks except for discoloration.en_US
dc.description.sponsorshipEge University Scientific Research Projects Coordinator [06 -TIP -024]en_US
dc.description.sponsorshipThis work was supported by a specific grant from Ege University Scientific Research Projects Coordinator (grant number: 06 -TIP -024) .en_US
dc.identifier.doi10.1016/j.radphyschem.2023.110893
dc.identifier.issn0969-806X
dc.identifier.issn1879-0895
dc.identifier.scopus2-s2.0-85150170532en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.radphyschem.2023.110893
dc.identifier.urihttps://hdl.handle.net/11454/100889
dc.identifier.volume208en_US
dc.identifier.wosWOS:000955862200001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofRadiation Physics and Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240825_Gen_US
dc.subjectSilicone elastomer prosthesisen_US
dc.subjectPhoton beamen_US
dc.subjectPhantomen_US
dc.subjectPercent depth doseen_US
dc.subjectDose profileen_US
dc.subjectThermoluminescence dosimetryen_US
dc.subjectMechanical-Propertiesen_US
dc.subjectSatisfactionen_US
dc.subjectElastomersen_US
dc.subjectDosimetryen_US
dc.titleThe interaction of ionizing radiation and silicone medical implants: Evaluation of the effects on radiotherapy dose distribution and alteration in the physical properties of the siliconeen_US
dc.typeArticleen_US

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