Fabrication of porous bone scaffolds using degradable and mouldable bacterial cellulose

Basit Öğe Kaydı
dc.authoridOZ, Yunus Emre/0000-0002-6418-5257
dc.authoridBingul, Nur Deniz/0000-0002-8800-4924
dc.authoridSendemir, Aylin/0000-0003-1818-6651
dc.authoridMORCIMEN, ZEHRA GUL/0000-0001-8954-9996
dc.contributor.authorOz, Yunus Emre
dc.contributor.authorBingul, Nur Deniz
dc.contributor.authorMorcimen, Zehra Gul
dc.contributor.authorSendemir, Aylin
dc.contributor.authorHames, Elif Esin
dc.date.accessioned2024-08-31T07:47:16Z
dc.date.available2024-08-31T07:47:16Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractBacterial cellulose (BC) is a biomaterial extensively studied in tissue engineering due to its favorable properties. Porosity, biocompatibility, biodegradability and mechanical durability are essential material properties for scaffold use in tissue engineering. This study aims to fabricate porous scaffolds using a moldable and degradable BC-HAp composite for bone tissue engineering. BC was produced by Komagataeibacter sucrofermentans under static culture conditions. The harvested BC membranes were purified and then mechanically shredded. BC oxidation was performed using different sodium periodate concentrations (0.05-0.5 M) and treatment times (0.5-12 h). Oxidized BCs (oxBC) were modified with hydroxyapatite (HAp), then were moulded, lyophilized, and characterized. The degradability of the scaffolds was determined for 45 days. Cytotoxic analysis of oxBC scaffolds was carried out for 7 days using the L929 fibroblast cell line. The oxidation degrees of the shredded BC samples were between 6.75 and 81%, which increased in line with the increasing concentration and application time of periodate. The scaffolds prepared using oxidized cellulose for 30 and 60 min (oxBC30 and oxBC60) preserved their integrity, These scaffolds showed a weight loss of 9% and 14% in 45 days, respectively. The pore distribution was between 50 and 450 mu m and concentrated in the 50-150 mu m range. The compression moduli were 88.72 kPa and 138.88 kPa for oxBC30-HAp and oxBC60-HAp, respectively. It was determined that oxBC did not show a significant difference in cell viability compared to the control groups and was not cytotoxic. In conclusion, degradable and more porous bone scaffolds were fabricated using mouldable oxBC.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkiye (TUBIdot;TAK); Scientific Research Foundation of Ege University [FOA-2020-21947]en_US
dc.description.sponsorshipOpen access funding provided by the Scientific and Technological Research Council of Turkiye (TUB & Idot;TAK). This work was supported by The Scientific Research Foundation of Ege University (Project number: FOA-2020-21947).en_US
dc.identifier.doi10.1007/s10570-024-05771-6
dc.identifier.endpage2935en_US
dc.identifier.issn0969-0239
dc.identifier.issn1572-882X
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85185904634en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2921en_US
dc.identifier.urihttps://doi.org/10.1007/s10570-024-05771-6
dc.identifier.urihttps://hdl.handle.net/11454/104375
dc.identifier.volume31en_US
dc.identifier.wosWOS:001171911500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofCelluloseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240831_Uen_US
dc.subjectBacterial Celluloseen_US
dc.subjectOxidationen_US
dc.subjectMouldableen_US
dc.subjectBone Scaffoldsen_US
dc.subjectDegradationen_US
dc.titleFabrication of porous bone scaffolds using degradable and mouldable bacterial celluloseen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu