Canakinumab: New treatment choice for systemic juvenile idiopathic arthritis

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dc.contributor.authorSozeri B.
dc.contributor.authorSevgi S.
dc.contributor.authorKasapcopur O.
dc.date.accessioned2019-10-26T21:26:31Z
dc.date.available2019-10-26T21:26:31Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractJuvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in children and systemic juvenile idiopathic arthritis (sJIA) accounts for 6-15% of the patients. It was found that there was spontaneous expression of IL-1ß in patients with sJIA. Canakinumab (ACZ885, Canakinumab) is a human anti-IL-1ß monoclonal antibody. Its mode of action is based on the neutralization of IL-1ß signaling which may result in the suppression of inflammation process in patients with disorders of autoinflammatory origin including sJIA. In addition to its use in the treatment of CAPS (cryopyrin-associated periodic syndromes) and acute gouty arthritis flares in many countries, the drug provides significant advantages over existing competitive therapies, including monthly SC administration and favorable safety profile. © 2015 Future Medicine Ltd.en_US
dc.identifier.doi10.2217/ijr.14.53
dc.identifier.endpage19en_US
dc.identifier.issn1758-4272
dc.identifier.issn1758-4272en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage13en_US
dc.identifier.urihttps://doi.org/10.2217/ijr.14.53
dc.identifier.urihttps://hdl.handle.net/11454/17351
dc.identifier.volume10en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherFuture Medicine Ltd.en_US
dc.relation.ispartofInternational Journal of Clinical Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectanti-interleukin-1en_US
dc.subjectcanakinumaben_US
dc.subjectsystemic juvenile idiopathic arthritisen_US
dc.titleCanakinumab: New treatment choice for systemic juvenile idiopathic arthritisen_US
dc.typeArticleen_US

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