Design of docetaxel-loaded polymeric nanoparticles: characterization, radiolabeling with Tc-99m and in vitro evaluation
| dc.contributor.author | Cetin, Oguz | |
| dc.contributor.author | Ichedef, Cigdem | |
| dc.contributor.author | Aydin, Burcu | |
| dc.contributor.author | Teksoz, Serap | |
| dc.date.accessioned | 2020-12-01T11:57:49Z | |
| dc.date.available | 2020-12-01T11:57:49Z | |
| dc.date.issued | 2020 | |
| dc.department | Ege Üniversitesi | en_US |
| dc.description.abstract | This research aims to develop a polymeric drug delivery system for docetaxel (DTX) and to investigate its radiotracer potential by in vitro. DTX loaded Poly(lactic acid)/Poly(ethylene glycol) diblock copolymer (PLA-PEG) was synthesized and radiolabeled with technetium-99m tricarbonyl core. PLA-PEG-DTX nanoparticles had a particle size and zeta potential 120 +/- 7.3 nm and - 24.66 +/- 1.5 mV respectively, which was further supported by SEM image. the radiolabeling efficiency of Tc-99m(CO)(3)-PLA-PEG-DTX was found to be 90 +/- 3.51%,. in vitro study was carried out on cancer cell lines (MCF7, MDA-MB-231) to examine the biological behavior of docetaxel loaded PLA-PEG nanoparticles. [GRAPHICS] . | en_US |
| dc.identifier.doi | 10.1007/s10967-020-07454-5 | |
| dc.identifier.issn | 0236-5731 | |
| dc.identifier.issn | 1588-2780 | |
| dc.identifier.issn | 0236-5731 | en_US |
| dc.identifier.issn | 1588-2780 | en_US |
| dc.identifier.scopus | 2-s2.0-85094158166 | en_US |
| dc.identifier.scopusquality | Q2 | en_US |
| dc.identifier.uri | https://doi.org/10.1007/s10967-020-07454-5 | |
| dc.identifier.uri | https://hdl.handle.net/11454/61818 | |
| dc.identifier.wos | WOS:000584877900005 | en_US |
| dc.identifier.wosquality | Q3 | en_US |
| dc.indekslendigikaynak | Web of Science | en_US |
| dc.indekslendigikaynak | Scopus | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Springer | en_US |
| dc.relation.ispartof | Journal of Radioanalytical and Nuclear Chemistry | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Docetaxel | en_US |
| dc.subject | polymeric nanoparticles | en_US |
| dc.subject | Technetium tricarbonyl core | en_US |
| dc.subject | Drug delivery system | en_US |
| dc.subject | Cell culture | en_US |
| dc.title | Design of docetaxel-loaded polymeric nanoparticles: characterization, radiolabeling with Tc-99m and in vitro evaluation | en_US |
| dc.type | Article | en_US |
