Radiation-Associated Chronic Dysphagia Assessment by Flexible Endoscopic Evaluation of Swallowing (FEES) in Head and Neck Cancer Patients: Swallowing-Related Structures and Radiation Dose-Volume Effect

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dc.contributor.authorAkagunduz, Ozlem Ozkaya
dc.contributor.authorEyigor, Sibel
dc.contributor.authorKirakli, Esra
dc.contributor.authorTavlayan, Emin
dc.contributor.authorCetin, Zeynep Erdogan
dc.contributor.authorKara, Gulsen
dc.contributor.authorEsassolak, Mustafa
dc.date.accessioned2019-10-27T09:46:51Z
dc.date.available2019-10-27T09:46:51Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractPurpose We aimed to restore dose-volume parameters of swallowing-related structures (SRSs) by evaluating long-term swallowing dysfunctions after radiotherapy (RT) in head and neck cancer patients (HNCPs). Materials and Methods Head and neck cancer patients whose pharyngeal region was involved in RT portal and treated with definitive RT/chemoradiotherapy (CRT) were included in the analyses. Patients underwent objective swallowing assessment by flexible endoscopic evaluation of swallowing (FEES). Volumes of SRSs that received 55 Gy (V-55) (mean dose [D-mean]) were evaluated according to the dose-volume histograms of each patient. For every SRS, optimal dose-volume cut-off values were determined by receiver operating characteristic curve analysis. Results Fifty-five patients at a median 20 months (range, 12-26 months) after their treatments were evaluated. There was a strong negative correlation between FEES scores and dose-volume parameters of SRS (r <= -0.5, P < .0001). According to our results, middle pharyngeal constrictor (MPC) and inferior pharyngeal constrictor (IPC) had a D-mean > 57 Gy, base of tongue (BOT) D-mean > 50 Gy, supraglottic larynx (SGL) and glottic larynx (GL) D-mean > 55 Gy, and cervical esophagus (CE) D-mean > 45 Gy. MPC V-55 > 70%, IPC V-55 > 50%, BOT V-55 > 65%, CE V-55 > 40%, and SGL and GL V-55 > 50% were significant predictors for dysphagia. Conclusion It was found that dysphagia correlates strongly with dose-volume parameters of SRSs. IPC, SGL, and CE were found to be structures significantly associated with dysphagia.en_US
dc.identifier.doi10.1177/0003489418804260
dc.identifier.endpage84en_US
dc.identifier.issn0003-4894
dc.identifier.issn1943-572X
dc.identifier.issn0003-4894en_US
dc.identifier.issn1943-572Xen_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage73en_US
dc.identifier.urihttps://doi.org/10.1177/0003489418804260
dc.identifier.urihttps://hdl.handle.net/11454/29331
dc.identifier.volume128en_US
dc.identifier.wosWOS:000454862500001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofAnnals of Otology Rhinology and Laryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectdysphagiaen_US
dc.subjectFEESen_US
dc.subjecthead and neck canceren_US
dc.subjectradiation dose-volume effectsen_US
dc.subjectswallowing-related structuresen_US
dc.titleRadiation-Associated Chronic Dysphagia Assessment by Flexible Endoscopic Evaluation of Swallowing (FEES) in Head and Neck Cancer Patients: Swallowing-Related Structures and Radiation Dose-Volume Effecten_US
dc.typeArticleen_US

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