Labeling of Sertraline with I-131 and investigation of its radiopharmaceutical potential

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dc.contributor.authorYurt, F
dc.contributor.authorUnak, P
dc.contributor.authorBiber, FZ
dc.date.accessioned2019-10-27T18:18:20Z
dc.date.available2019-10-27T18:18:20Z
dc.date.issued2002
dc.departmentEge Üniversitesien_US
dc.description.abstractSertraline is an antidepressant drug. Sertraline was labeled with I-131 by using iodogen method. Labeling yield was 85-90% and specific activity was approximately 64.75 GBq/mmol. The purification of radioiodinated Sertraline was performed by Sep Pak C-18 plus and the radiochemical purity was determined to be over 99%. Biodistribution studies were carried out by male Albino Wistar rats. The percentage of injected radioactivity per gram of tissue was calculated, and these data versus time curves were generated for organs and brain regions. The results showed that I-131 labeled Sertraline may be a promising radiopharmaceutical for the investigation of serotonin 5-HT receptor functions of brain.en_US
dc.identifier.doi10.1023/A:1014856024831
dc.identifier.endpage244en_US
dc.identifier.issn0236-5731
dc.identifier.issn0236-5731en_US
dc.identifier.issue2en_US
dc.identifier.startpage241en_US
dc.identifier.urihttps://doi.org/10.1023/A:1014856024831
dc.identifier.urihttps://hdl.handle.net/11454/35465
dc.identifier.volume251en_US
dc.identifier.wosWOS:000174193800009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherKluwer Academic Publen_US
dc.relation.ispartofJournal of Radioanalytical and Nuclear Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleLabeling of Sertraline with I-131 and investigation of its radiopharmaceutical potentialen_US
dc.typeArticleen_US

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