National Multi-Center Observational Retrospective Study to Understand Treatment Patterns and Outcomes for Stage III Non-Small Cell Lung Cancer Patients in Turkey: Turkish Society for Radiation Oncology Study, STONE Trial

Basit Öğe Kaydı
dc.authoridBERBER, TANJU/0000-0002-4087-4760
dc.authoridYalman, Deniz/0000-0002-4010-8353
dc.authorscopusid6701367993
dc.authorscopusid26432287500
dc.authorscopusid7801341856
dc.authorscopusid6602174698
dc.authorscopusid26537255800
dc.authorscopusid16304281300
dc.authorscopusid8894510900
dc.authorwosidBERBER, TANJU/T-1170-2018
dc.authorwosidDuru Birgi, Sümerya/GZH-1201-2022
dc.authorwosidYalman, Deniz/ABG-5077-2020
dc.contributor.authorOnal, Cem
dc.contributor.authorDemiral, Ayse Nur
dc.contributor.authorAtalar, Banu
dc.contributor.authorYalman, Deniz
dc.contributor.authorDagoglu, Nergiz
dc.contributor.authorHurmuz, Pervin
dc.contributor.authorErpolat, Petek
dc.date.accessioned2023-01-12T20:17:12Z
dc.date.available2023-01-12T20:17:12Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractThis study investigated treatment patterns and outcomes in patients with inoperable stage III non-small cell lung cancer (NSCLC) treated with radiotherapy (RT) in Turkey. We included 492 patients with stage III NSCLC in this multi-center retrospective study. Pa-tient demographics, clinical characteristics, and clinical treatment patterns from the time of the initial diagnosis to disease progression were recorded. Additionally, the prognostic factors predicting overall survival (OS) and progression-free survival (PFS) were analyzed. For the initial treatment, 429 patients (89.2%) received chemotherapy and RT, whereas 53 patients (10.8%) were treated only with RT. The first disease progression occurred in 288 patients (58.4%) at 9.3 months (median) after the initial treatment, and 64.6% re-ceived treatment after first progression. The second disease progression occurred in 30 patients, and 20 patients (66.7%) received treatment. Median OS and PFS were 27.0 months and 13.4 months, respectively. Age (p< 0.001), stage (p= 0.04), poor performance score (PS) (p= 0.03) and RT doses (p= 0.002) were independent predictors for OS and PFS in our multivariate analysis. Additional significant predictors for OS in the multivariate analysis were gender (p= 0.004), treatment period (0.02), and irradiation technique (p= 0.02). Disease progression occurred in nearly 58% of the patients, and one-third of these patients remained untreated during the disease progression. These findings indicate a need for additional treatment options in patients with unresectable stage III NSCLC with high-risk features, namely older age, stage IIIB disease, poor PS, and lower RT doses.en_US
dc.description.sponsorshipAstraZeneca Turkeyen_US
dc.description.sponsorshipAstraZeneca Turkey provided the funding for the study.en_US
dc.identifier.doi10.4999/uhod.225876
dc.identifier.endpage34en_US
dc.identifier.issn1306-133X
dc.identifier.issn1306-133Xen_US
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85123064473en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage23en_US
dc.identifier.urihttps://doi.org/10.4999/uhod.225876
dc.identifier.urihttps://hdl.handle.net/11454/78841
dc.identifier.volume32en_US
dc.identifier.wosWOS:000747924400001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAkad Doktorlar Yayinevien_US
dc.relation.ispartofUhod-Uluslararasi Hematoloji-Onkoloji Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLung canceren_US
dc.subjectStage IIIen_US
dc.subjectTreatment patternsen_US
dc.subjectChemotherapyen_US
dc.subjectRadiotherapyen_US
dc.subjectTnm Classificationen_US
dc.subjectOpen-Labelen_US
dc.subjectChemoradiotherapyen_US
dc.subjectChemotherapyen_US
dc.subjectManagementen_US
dc.subjectProposalsen_US
dc.subjectGroupingsen_US
dc.subjectNivolumaben_US
dc.subjectSurvivalen_US
dc.subjectRevisionen_US
dc.titleNational Multi-Center Observational Retrospective Study to Understand Treatment Patterns and Outcomes for Stage III Non-Small Cell Lung Cancer Patients in Turkey: Turkish Society for Radiation Oncology Study, STONE Trialen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu