Evaluation of Several Microalgal Extracts as Bioactive Metabolites as Potential Pharmaceutical Compounds

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dc.contributor.authorGurlek, Ceren
dc.contributor.authorYarkent, Cagla
dc.contributor.authorKose, Ayse
dc.contributor.authorOral, Izel
dc.contributor.authorOncel, Suphi S.
dc.contributor.authorElibol, Murat
dc.date.accessioned2020-12-01T12:05:44Z
dc.date.available2020-12-01T12:05:44Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractThe nature derived therapeutics is getting intense attention rather than chemical synthesis and synthetic ones. Today the expansion of natural bioactive molecule market is started to be dominated and generic drug and therapeutic understanding looks like to leave its place to a new horizon. Thus, natural originated therapeutics under controlled production conditions are of importance. Besides the public attention on natural molecules are also gain advance and the demand on this bioactive molecules is also increasing dramatically. the bioactive molecules from microalgae show antioxidant, antibacterial, antiviral, anticancer, skin regenerative, sunscreen, antihypertensive, neuroprotective and immunostimulatory effects which are favorable for pharmaceutical, nutraceutical and cosmetics industry. Also a new concept known as functional nutrition also broaden the acceptability and utilization of microalgae derived bioactive metabolites in new dietary formulations. the expansion of microalgal biotechnology and the number of research gained from the role of biologically active microalgal metabolites display the emergence of the microalgae farming for new pharmaceutical formulations. in this study, we prepared solvent and water extracts of G. sulphuraria, N. texensis, S. bacillaris, E. carotinosa, C. minutissima, S. limacinum, C. cohnii, and C. vulgaris. Antioxidant activity using DPPH radical scavenging activity and total phenolic compounds were measured from the methanolic extracts and water extracts. With the bioactive extracts cytotoxicity test were performed on Hep-G2 and B16-F10 cell lines. the results display potential onset of novel therapeutic compounds derived from microalgae.en_US
dc.description.sponsorshipScientific and Technological Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [216M390]en_US
dc.description.sponsorshipThis study is a joint project with Ege University (Turkey), Liege University (Belgium), and Daegu Haany University (South Korea) named, KONNECT (Exploring the potential bioactive molecules from microalgae and understanding of their gene regulations-ALGACTIVE). the authors would like to thank the Scientific and Technological Council of Turkey (TUBITAK) for funding the project KONNECT 216M390. the authors declare that there is no conflict of interest.en_US
dc.identifier.doi10.1007/978-3-030-17971-7_41
dc.identifier.endpage272en_US
dc.identifier.isbn978-3-030-17971-7; 978-3-030-17970-0
dc.identifier.issn1680-0737
dc.identifier.startpage267en_US
dc.identifier.urihttps://doi.org/10.1007/978-3-030-17971-7_41
dc.identifier.urihttps://hdl.handle.net/11454/63072
dc.identifier.volume73en_US
dc.identifier.wosWOS:000491311000041en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofProceedings of the International Conference on Medical and Biological Engineering, Cmbebih 2019en_US
dc.relation.ispartofseriesIFMBE Proceedings
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMicroalgaeen_US
dc.subjectCyanobacteriaen_US
dc.subjectBioactivityen_US
dc.subjectPharmaceuticalen_US
dc.subjectExtractionen_US
dc.titleEvaluation of Several Microalgal Extracts as Bioactive Metabolites as Potential Pharmaceutical Compoundsen_US
dc.typeConference Objecten_US

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