Synthesis of axially disubstituted silicon phthalocyanines and investigation of their in vitro cytotoxic/phototoxic anticancer activities

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dc.contributor.authorYurt, F.
dc.contributor.authorSaka, E.T.
dc.contributor.authorBiyiklioglu, Z.
dc.contributor.authorTunçel, A.
dc.contributor.authorOzel, D.
dc.contributor.authorOcakoglu, K.
dc.date.accessioned2020-12-01T11:53:01Z
dc.date.available2020-12-01T11:53:01Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractIn this study, two SiPcs have been selected and the photodynamic therapy potentials were evaluated of the Pcs. Synthesis of Axially 2-decyn-1-oxy disubstituted Es-SiPc-2 was newly synthesized by the reaction of SiPcCl2 with 2-decyn-1-ol in the presence of NaH in toluene. Furthermore, their nuclear imaging potentials were evaluated in human colon adenocarcinoma (HT-29) and human lung fibroblast cell (WI-38) cell lines. The uptake results have indicated that Es-SiPc labeled with 131I radionuclide (131I-Es-SiPc) was approximately 2-fold higher in the HT-29 cell line than the WI-38 cell line. In other words, the target/non-target tissue ratio is defined as two in the HT-29/WI-38 cell lines. Besides, the uptake values of 131I-Es-SiPc were found to be higher than 131I-Es-SiPc-2. 131I-Es-SiPc and 131I-Es-SiPc-2 are promising for imaging or treating colon adenocarcinoma. In vitro photodynamic therapy (PDT) studies have shown that both compounds are suitable and can be used in this field. Also, Es-SiPc has been shown to have higher phototoxicity than Es-SiPc-2. © 2020 World Scientific Publishing Company.en_US
dc.identifier.doi10.1142/S1088424620500455
dc.identifier.issn1088-4246
dc.identifier.issn1088-4246en_US
dc.identifier.scopus2-s2.0-85093503758en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1142/S1088424620500455
dc.identifier.urihttps://hdl.handle.net/11454/61714
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWorld Scientificen_US
dc.relation.ispartofJournal of Porphyrins and Phthalocyaninesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject1 3 1 Ien_US
dc.subjectcolon adenocarcinomaen_US
dc.subjectphotodynamic therapyen_US
dc.subjectsilicon phthalocyanineen_US
dc.titleSynthesis of axially disubstituted silicon phthalocyanines and investigation of their in vitro cytotoxic/phototoxic anticancer activitiesen_US
dc.typeArticleen_US

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