Effect of Predator Bacteria Bdellovibrio bacteriovorus on Clinical Pathogens and Biofilms

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dc.authorscopusid58124816100
dc.authorscopusid57196047480
dc.authorscopusid6507459615
dc.authorscopusid6508260544
dc.contributor.authorKahraman Vatansever, Selcan
dc.contributor.authorTekintas, Yamac
dc.contributor.authorCilli, Fatma Feriha
dc.contributor.authorHosgor-Limoncu, Mine
dc.date.accessioned2024-08-25T18:32:13Z
dc.date.available2024-08-25T18:32:13Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractAntimicrobial resistance has become one of the most important public health problems of our century. In addition to the spread of resistance, biofilm production also makes the treatment of infections increasingly difficult. Therefore, this study, it was aimed to investigate the effect of the predator bacterium Bdellovibrio bacteriovorus HD100 on various clinical pathogens and their biofilms. A large panel of Gram-positive and negative clinical isolates were included in the study. The double-layer agar method was used to optimize the cultivation of predatory bacteria. The effectiveness of Bdellovibrio bacteriovorus HD 100 on planktonic cells and biofilms, was determined by co-culture and crystal violet staining methods, respectively. The antibiofilm activity was also visualized via scanning electron microscopy. The predator bacteria was found effective against most of the Gram-negative isolates. But it was determined that the lowest activity among these isolates was shown to Pseudomonas aeruginosa and Acinetobacter baumannii. Although it is known that B. bacteriovorus does not predate on Gram-positive isolates, interestingly, Staphylococci species included in this study were found to be inhibited in co-culture studies. As determined in co-culture and biofilm studies, B. bacteriovorus can be used to control both bacterial growth and biofilms in most Gram-negative species. Interestingly, our data also suggest that predatory bacteria may also be effective against Gram-positive bacterial biofilms in addition to Staphylococcus aureus. Although the evaluation of different species of isolates in this study demonstrates the potential of predatory bacteria, the host specificity and the relation of prey and predator need to be demonstrated.en_US
dc.identifier.doi10.1007/s12088-023-01071-y
dc.identifier.issn0046-8991
dc.identifier.issn0973-7715
dc.identifier.scopus2-s2.0-85149261524en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1007/s12088-023-01071-y
dc.identifier.urihttps://hdl.handle.net/11454/100172
dc.identifier.wosWOS:000942682100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofIndian Journal of Microbiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240825_Gen_US
dc.subjectAntimicrobial resistanceen_US
dc.subjectBdellovibrio bacteriovorusen_US
dc.subjectBiofilmen_US
dc.subjectPredationen_US
dc.subjectStaphylococcus-Epidermidisen_US
dc.subjectSusceptibilityen_US
dc.subjectResistanceen_US
dc.subjectImpacten_US
dc.titleEffect of Predator Bacteria Bdellovibrio bacteriovorus on Clinical Pathogens and Biofilmsen_US
dc.typeArticleen_US

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