Effect of Pupil Size on Fixed-Luminance Flicker Full-Field Electroretinogram Magnitude

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dc.authorscopusid57224501261
dc.authorscopusid57467503400
dc.authorscopusid57960669100
dc.authorscopusid56088721000
dc.authorscopusid57224513953
dc.authorscopusid57221874508
dc.authorscopusid57194568406
dc.contributor.authorMobasserian A.
dc.contributor.authorZaidi M.
dc.contributor.authorHalim S.
dc.contributor.authorHwang J.J.
dc.contributor.authorRegenold J.
dc.contributor.authorAkhavanrezayat A.
dc.contributor.authorKaraca I.
dc.date.accessioned2023-01-12T20:24:11Z
dc.date.available2023-01-12T20:24:11Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractPurpose: Diopsys® NOVA fixed-luminance flicker full-field electroretinogram (ffERG) device is a potential adjunct to conventional flicker ffERG testing for assessing cone cell function. Magnitude of measured electrical response is known to vary with pupil size in conventional ffERG testing. The index study characterizes the relationship between magnitude of measured electrical activity and pupil size, both pupil diameter and pupil area, for this device. Methods: Seventeen patients (34 eyes) with no known ocular diseases were enrolled in the study. Electrophysiologic function of cone cells was evaluated using fixed-luminance flicker ffERG before and after dilation. Linear regression models, with inter-eye correlations controlled as fixed-effects, were used to characterize the effect of pupil dilation on the magnitude of the measured responses. Results: Mean age of study patients was 33.5 (standard deviation 7.4 years), and 35.3% of the subjects were female. Mean value of electrical response magnitude was 10.07±2.79µV before dilation and 15.30±4.08µV after dilation. The correlations of ERG magnitude with pupil diameter and with pupil area were not significant for either dilated or undilated eyes considered separately but were highly significant (p<0.001) for dilated and undilated eyes considered in aggregate. ERG magnitude tended to increase by 1.08 µV for every 1 mm increase in pupillary diameter. Conclusion: An increase in pupil size, both pupil diameter and pupil area, is significantly associated with an increase in flicker ffERG magnitude recorded by the Diopsys device, suggesting that pupil size should be measured and considered when making clinical judgments based on the flicker ffERGs recorded by the device, and that pupil size-specific reference ranges could improve the clinical utility of the device. © 2022 Mobasserian et al.en_US
dc.description.sponsorship2773318en_US
dc.description.sponsorshipThe Diopsys ERG device at the Byers Eye Institute is on loan from Diopsys, Inc. for clinical and research usage. The abstract of this paper was presented at the Association for Research in Vision and Ophthalmology (ARVO) 2021 Conference as a poster presentation with interim findings. The poster’s abstract was published in “Poster Abstracts” in the Investigative Ophthalmology & Visual Science (IOVS) journal. URL: https://iovs.arvojournals.org/article.aspx?arti cleid=2773318. Azadeh Mobasserian and Moosa Zaidi are co-first authors in this work.en_US
dc.identifier.doi10.2147/OPTH.S382207
dc.identifier.endpage3740en_US
dc.identifier.issn11775467
dc.identifier.issn1177-5467en_US
dc.identifier.scopus2-s2.0-85141663415en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage3733en_US
dc.identifier.urihttps://doi.org/10.2147/OPTH.S382207
dc.identifier.urihttps://hdl.handle.net/11454/79841
dc.identifier.volume16en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherDove Medical Press Ltden_US
dc.relation.ispartofClinical Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiopsysen_US
dc.subjectelectroretinogramen_US
dc.subjectERGen_US
dc.subjectflicker ERGen_US
dc.subjectmagnitudeen_US
dc.subjectpupilen_US
dc.titleEffect of Pupil Size on Fixed-Luminance Flicker Full-Field Electroretinogram Magnitudeen_US
dc.typeArticleen_US

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