Extraction, radiolabeling and in vivo biological evaluation of I-131 labeled egonol glycosides extract

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dc.contributor.authorAkgul, Yurdanur
dc.contributor.authorPazar, Erdinc
dc.contributor.authorYilmaz, Habibe
dc.contributor.authorLambrecht, Fatma Yurt
dc.contributor.authorYilmaz, Osman
dc.contributor.authorSanlier, Senay Hamarat
dc.date.accessioned2019-10-27T23:00:01Z
dc.date.available2019-10-27T23:00:01Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractCrude extract of S. officinalis L. was found to have suspending agent, hemolytic, antitumor, antioxidant and antimicrobial activities. Its major components benzofurans and benzofuran glycosides have antifungal, anticancer, antibacterial and anticomplement activities and display acetylcholinesterase-cyclooxygenase inhibitory and cytotoxic properties. Recently, it has been reported that egonolgentiobioside is a valuable target for structural modification and warrants further investigation for its potential as a novel pharmaceutical tool for the prevention of estrogen deficiency induced diseases. The aim of the current study is to perform in vivo biological evaluation of a glycosides extract, which was isolated from the fruits endocarp of Styrax officinalis L, identified as egonolgentiobioside and homoegonolgentiobioside and labeled with I-131. The radiolabeled glycosides extract was labeled with I-131 with high yield. The labeled obtained radiolabeled compound was found to be quite stable and lipophilic. In order to determine its tissue distribution, an in vivo study was performed using healthy female Albino Wistar rats injected by I-131-glycosides. The biodistribution results showed that clearance of the radiolabeled compound is through the hepatobiliary pathway. The experimental study indicated that the radiolabeled glycosides extract accumulated in the large intestine. Therefore, the potential of I-131-glycosidesmight be evaluated in colon cancer cell lines and this might be a promising of tumor-imaging agent.en_US
dc.identifier.doi10.1515/ract-2014-2304
dc.identifier.endpage462en_US
dc.identifier.issn0033-8230
dc.identifier.issn0033-8230en_US
dc.identifier.issue6en_US
dc.identifier.startpage457en_US
dc.identifier.urihttps://doi.org/10.1515/ract-2014-2304
dc.identifier.urihttps://hdl.handle.net/11454/51930
dc.identifier.volume103en_US
dc.identifier.wosWOS:000355624200006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofRadiochimica Actaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEgonol glycosidesen_US
dc.subjectI-131-glycosides-extracten_US
dc.subjectbiodistributionen_US
dc.titleExtraction, radiolabeling and in vivo biological evaluation of I-131 labeled egonol glycosides extracten_US
dc.typeArticleen_US

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