Controlled release of anticancer drug Paclitaxel using nano-structured amphiphilic star-hyperbranched block copolymers

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dc.contributor.authorGeyik, Caner
dc.contributor.authorCiftci, Mustafa
dc.contributor.authorDemir, Bilal
dc.contributor.authorGuler, Bahar
dc.contributor.authorOzkaya, A. Burak
dc.contributor.authorGumus, Z. Pinar
dc.contributor.authorBarlas, F. Baris
dc.contributor.authorDemirkol, Dilek Odaci
dc.contributor.authorCoskunol, Hakan
dc.contributor.authorTimur, Suna
dc.contributor.authorYagci, Yusuf
dc.date.accessioned2019-10-27T22:29:37Z
dc.date.available2019-10-27T22:29:37Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractIn the present study, two amphiphilic star-hyperbranched copolymers based on poly(methyl methacrylate)-b-poly(2-hydroxyethyl methacrylate) (PMMA-b-PHEMA), with different hydrophilic PHEMA segment contents (PMMA-b-PHEMA-1, and PMMA-b-PHEMA-2), were synthesized, and their drug loading and release profiles were examined using Paclitaxel (PTX) as a model drug. The drug loading capacities and encapsulation efficiencies were found to be similar in both polymers. The encapsulation efficiencies were found to be prominent at 98% and 98.5% for PMMA-b-PHEMA-1 and PMMA-b-PHEMA-2, respectively. On the other hand, the drug release behaviors varied in favor of the block copolymer comprising shorter PHEMA chains (PMMA-b-PHEMA-1). Additionally, to assess the biological effects of PTX-loaded polymers, human non-small cell lung carcinoma (A549) cells were used. Cell viability and cell cycle analysis showed that both polymers were non-toxic to cells. The cytotoxic effect of PTX-loaded PMMA-b-PHEMA-1 on A 549 cells was greater (66.49% cell viability at 5.0 ng mL(-1) PTX) than that of PMMA-b-PHEMA-2 (72.47% cell viability at 5.0 ng mL(-1) PTX), consistent with the drug release experiments.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [113Z529, 113Z234]en_US
dc.description.sponsorshipThe authors thank the Scientific and Technological Research Council of Turkey (TUBITAK, project no. 113Z529 and 113Z234) for financial support. We also thank the Research and Education Laboratory of Ege University, School of Medicine (AREL) for flow cytometric analyses, Ege University, Nuclear Science Institute for DLS analyses and Middle East Technical University Central Laboratory for TEM analyses. There is no conflict of interest associated with this manuscript.en_US
dc.identifier.doi10.1039/c5py00780a
dc.identifier.endpage5477en_US
dc.identifier.issn1759-9954
dc.identifier.issn1759-9962
dc.identifier.issn1759-9954en_US
dc.identifier.issn1759-9962en_US
dc.identifier.issue30en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage5470en_US
dc.identifier.urihttps://doi.org/10.1039/c5py00780a
dc.identifier.urihttps://hdl.handle.net/11454/51132
dc.identifier.volume6en_US
dc.identifier.wosWOS:000358305900014en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherRoyal Soc Chemistryen_US
dc.relation.ispartofPolymer Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleControlled release of anticancer drug Paclitaxel using nano-structured amphiphilic star-hyperbranched block copolymersen_US
dc.typeArticleen_US

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