Carbon dots and curcumin-loaded CD44-Targeted liposomes for imaging and tracking cancer chemotherapy: A multi-purpose tool for theranostics

Basit Öğe Kaydı
dc.contributor.authorDemir, Bilal
dc.contributor.authorMoulahoum, Hichem
dc.contributor.authorGhorbanizamani, Faezeh
dc.contributor.authorBarlas, F. Baris
dc.contributor.authorYesiltepe, Ozan
dc.contributor.authorGumus, Z. Pinar
dc.contributor.authorTimur, Suna
dc.date.accessioned2021-05-03T20:21:30Z
dc.date.available2021-05-03T20:21:30Z
dc.date.issued2021
dc.departmentEge Üniversitesien_US
dc.description.abstractGrowing needs in biomedical applications have driven the development of multifunctional nanoparticles towards theranostically-engineered multimodal platforms. Many strategies for point-effective cellular uptake of theranostics have been described. in this report, multifunctional nanostructures were designed and synthesized as a novel theranostic platform. Liposomes were loaded with curcumin as a therapeutic agent and carbon dots (CDs) as a contrast molecule. Anti-CD44 antibodies were bioconjugated on the liposomal surface to obtain an active targeting nanocarrier. After synthesis, the relative characterization of the vesicles was performed using DLS and TEM techniques. in vitro analysis was conducted to investigate the multimodal properties of the theranostic via testing its toxicity, cell uptake, bioimaging, and chemo/radiotherapy applications on two different cell lines. 3D holographic microscopy was employed to track the treatment effects during experimentation. Results indicated that these particles are efficient tools for clinical applications due to their fluorescent characteristic and increased bioperformance.en_US
dc.description.sponsorshipEge University, Scientific Research FoundationEge University [2017 FEN 007]en_US
dc.description.sponsorshipEge University, Scientific Research Foundation is acknowledged for the support (Project no: 2017 FEN 007) .en_US
dc.identifier.doi10.1016/j.jddst.2021.102363
dc.identifier.issn1773-2247
dc.identifier.issn2588-8943
dc.identifier.issn1773-2247en_US
dc.identifier.issn2588-8943en_US
dc.identifier.scopus2-s2.0-85099980981en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.jddst.2021.102363
dc.identifier.urihttps://hdl.handle.net/11454/69350
dc.identifier.volume62en_US
dc.identifier.wosWOS:000629394700002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Drug Delivery Science and Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTheranosticsen_US
dc.subjectCarbon dotsen_US
dc.subjectCurcuminen_US
dc.subjectLiposomeen_US
dc.subjectCD44en_US
dc.subjectBioconjugationen_US
dc.titleCarbon dots and curcumin-loaded CD44-Targeted liposomes for imaging and tracking cancer chemotherapy: A multi-purpose tool for theranosticsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu