One-Pot Photo-Induced Sequential CuAAC and Thiol-Ene Click Strategy for Bioactive Macromolecular Synthesis

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dc.contributor.authorDoran, Sean
dc.contributor.authorMurtezi, Eljesa
dc.contributor.authorBarlas, Firat Baris
dc.contributor.authorTimur, Suna
dc.contributor.authorYagci, Yusuf
dc.date.accessioned2019-10-27T22:14:25Z
dc.date.available2019-10-27T22:14:25Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractConceptually new one-pot photoinduced sequential click reactions were implemented to yield novel block copolymers with the ability for cell adhesion. Poly(epsilon-caprolcatone) possessing clickable functional groups at the chain ends, namely alpha-alkynyl-omega-alkenyl-poly(epsilon-caprolactone) (A-PCL-MA), was prepared by ring-opening polymerization of epsilon-caprolactone using propargyl alcohol in the presence of stannous octoate at 110 degrees C followed by esterification with methacrylic acid. Azide-functional poly(methyl methacrylate) (PMMA-N-3) was prepared independently by atom transfer radical polymerization (ATRP) followed by an azidation process using sodium azide. Finally, A-PCL-MA was reacted with PMMA-N-3 and N-acetyl-L-cysteine (NAC) in a one-pot process through photoinduced sequential click reactions to furnish desired bioactive block copolymer (PMMA-b-PCL-NAC). A matrix for cell adhesion was then prepared from the yielded block copolymer PMMA-b-PCL-NAC and cell proliferation on the matrix was measured. Cells from the Vero cell line (African green monkey kidney epithelial) were incubated on the matrix, and after 48 h, they showed greater cell proliferation than the commercially available cell culture plates used as comparison.en_US
dc.description.sponsorshipBrain Circulation Scheme; EC-FP7Marie Curie Actions-People-COFUND; BIDEBTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK)en_US
dc.description.sponsorshipThe authors of this work would like to acknowledge and thank TUBITAK for the 2236 Co-Funded Brain Circulation Scheme (co-circulation scheme) partially supported by the EC-FP7Marie Curie Actions-People-COFUND and coordinated by BIDEB as a source of funding.en_US
dc.identifier.doi10.1021/ma5007039
dc.identifier.endpage3613en_US
dc.identifier.issn0024-9297
dc.identifier.issn1520-5835
dc.identifier.issn0024-9297en_US
dc.identifier.issn1520-5835en_US
dc.identifier.issue11en_US
dc.identifier.startpage3608en_US
dc.identifier.urihttps://doi.org/10.1021/ma5007039
dc.identifier.urihttps://hdl.handle.net/11454/50003
dc.identifier.volume47en_US
dc.identifier.wosWOS:000337199000010en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherAmer Chemical Socen_US
dc.relation.ispartofMacromoleculesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleOne-Pot Photo-Induced Sequential CuAAC and Thiol-Ene Click Strategy for Bioactive Macromolecular Synthesisen_US
dc.typeArticleen_US

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