Antimicrobial and wound healing properties of cotton fabrics functionalized with oil-in-water emulsions containing Pinus brutia bark extract and Pycnogenol (R) for biomedical applications

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dc.contributor.authorSecim-Karakaya, Pelin
dc.contributor.authorSaglam-Metiner, Pelin
dc.contributor.authorYesil-Celiktas, Ozlem
dc.date.accessioned2021-05-03T20:21:31Z
dc.date.available2021-05-03T20:21:31Z
dc.date.issued2021
dc.departmentEge Üniversitesien_US
dc.description.abstractTopical formulations containing 1-2% of Pinus brutia bark extract and Pycnogenol (R) have been prepared to investigate the effect of flavonoids on the stability of O/W emulsions, which were subjected to physicochemical and thermal stability tests. The formulations have been applied to cotton fabrics to evaluate antimicrobial properties against Staphylococcus aureus, Escherichia coli, Candida albicans and Aspergillus brasiliensis. Furthermore, prepared cotton fabrics have been tested on keratinocytes seeded in cell culture inserts for wound healing. Results of freeze thaw cycle test indicated enhanced thermo-stability with no major changes in pH and viscosity, likewise the results of centrifugation assay. However, the addition of Pycnogenol (R) has tremendously decreased the viscosity of the topical formulation (10,900 cp.). in terms of antimicrobial activity, 2% P. brutia treated cotton fabrics decreased the proliferation of Aspergillus brasiliensis 78.8%, which were more effective than that of Pycnogenol (R) formulation (62.9%). As for wound healing, 2% P. brutia treated cotton fabrics increased HaCaT keratinocyte cell proliferation and accelerated the cell-free gap closure compared to Pycnogenol (R) and untreated control groups. The obtained results indicate the utilization of pine bark for developing an eco-friendly natural antifungal finish for medical textiles.en_US
dc.description.sponsorshipResearch fund of Ege UniversityEge University [15MUH051]en_US
dc.description.sponsorshipThe financial support provided by the Research fund of Ege University (15MUH051) is highly appreciated.en_US
dc.identifier.doi10.1007/s10616-021-00467-2
dc.identifier.issn0920-9069
dc.identifier.issn1573-0778
dc.identifier.issn0920-9069en_US
dc.identifier.issn1573-0778en_US
dc.identifier.scopus2-s2.0-85103424324en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1007/s10616-021-00467-2
dc.identifier.urihttps://hdl.handle.net/11454/69357
dc.identifier.wosWOS:000635454200001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofCytotechnologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTopical formulationen_US
dc.subjectWound healingen_US
dc.subjectCell proliferationen_US
dc.subjectAntifungalen_US
dc.subjectPinus brutiaen_US
dc.subjectPycnogenol&#174en_US
dc.titleAntimicrobial and wound healing properties of cotton fabrics functionalized with oil-in-water emulsions containing Pinus brutia bark extract and Pycnogenol (R) for biomedical applicationsen_US
dc.typeArticleen_US

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