Histopathological and immunohistochemical features of 32 cases of splenic B-cell lymphoma and leukemia

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dc.contributor.authorKaçar Döger F.
dc.contributor.authorHekimgil M.
dc.contributor.authorErtan Y.
dc.contributor.authorSarsik B.
dc.contributor.authorSoydan S.
dc.contributor.authorNeşe N.
dc.date.accessioned2019-10-26T23:55:38Z
dc.date.available2019-10-26T23:55:38Z
dc.date.issued2009
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: Leukemias and non-Hodgkin lymphomas commonly involve the spleen or originate primarily in the spleen and then spread to other sites. Material and Methods: In this retrospective study, we examined the histopathological and immunohistochemical characteristics of 32 cases of primary or secondary splenic B-cell lymphoma and leukemia, in which the diagnosis was established according to the World Health Organization (WHO) classification. The immunohistochemical panel included ALK-1, BCL-2, BCL-6, CD3, CD5, CD10, CD20, CD21, CD23, CD30, CD43, cyclin D1, Ki-67, and TRAP. Results: There was no other nodal or extranodal disease involvement in the majority of patients diagnosed with lymphoma at the time of presentation, while cases of leukemia had undergone splenectomy for palliative purposes. The diagnoses were as follows: 11 cases of hairy cell leukemia (HCL, 34.4%), 8 cases of splenic marginal zone lymphoma (SMZL, 25%), 8 cases of diffuse large B-cell lymphoma (DLBCL, 25%) including 1 T-cell-rich B-cell lymphoma (TCRBCL), 4 cases of mantle cell lymphoma (MCL, 12.5%), and 1 prolymphocytic leukemia (PLL, 3.1%). Conclusion: Overall assessment of spleen, liver, bone marrow, and lymph node examinations and a detailed correlation of the histopathological and immunohistochemical features with the clinical findings are very helpful and usually lead to the final diagnosis in most cases of primary or secondary splenic B-cell lymphoma and leukemia. Copyright © 2009 by Türkiye Klinikleri.en_US
dc.identifier.endpage1472en_US
dc.identifier.issn1300-0292
dc.identifier.issn1300-0292en_US
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage1463en_US
dc.identifier.urihttps://hdl.handle.net/11454/20664
dc.identifier.volume29en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofTurkiye Klinikleri Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectB-cellen_US
dc.subjectLeukemiaen_US
dc.subjectLymphomaen_US
dc.subjectNon-Hodgkinen_US
dc.subjectSplenic neoplasmsen_US
dc.titleHistopathological and immunohistochemical features of 32 cases of splenic B-cell lymphoma and leukemiaen_US
dc.typeArticleen_US

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